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Structure-guided Discovery of Dual-recognition Chemibodies

Small molecules and antibodies each have advantages and limitations as therapeutics. Here, we present for the first time to our knowledge, the structure-guided design of “chemibodies” as small molecule-antibody hybrids that offer dual recognition of a single target by both a small molecule and an an...

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Detalles Bibliográficos
Autores principales:	Cheng, Alan C., Doherty, Elizabeth M., Johnstone, Sheree, DiMauro, Erin F., Dao, Jennifer, Luthra, Abhinav, Ye, Jay, Tang, Jie, Nixey, Thomas, Min, Xiaoshan, Tagari, Philip, Miranda, Les P., Wang, Zhulun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954141/ https://www.ncbi.nlm.nih.gov/pubmed/29765112 http://dx.doi.org/10.1038/s41598-018-25848-0

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