Cargando…

Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants

Our objectives were to define the microstructural developmental trajectory of six corpus callosum subregions and identify perinatal clinical factors that influence early development of these subregions in very preterm infants. We performed a longitudinal cohort study of very preterm infants (32 week...

Descripción completa

Detalles Bibliográficos
Autores principales: Teli, Radhika, Hay, Margaret, Hershey, Alexa, Kumar, Manoj, Yin, Han, Parikh, Nehal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954149/
https://www.ncbi.nlm.nih.gov/pubmed/29765059
http://dx.doi.org/10.1038/s41598-018-25245-7
_version_ 1783323466673422336
author Teli, Radhika
Hay, Margaret
Hershey, Alexa
Kumar, Manoj
Yin, Han
Parikh, Nehal A.
author_facet Teli, Radhika
Hay, Margaret
Hershey, Alexa
Kumar, Manoj
Yin, Han
Parikh, Nehal A.
author_sort Teli, Radhika
collection PubMed
description Our objectives were to define the microstructural developmental trajectory of six corpus callosum subregions and identify perinatal clinical factors that influence early development of these subregions in very preterm infants. We performed a longitudinal cohort study of very preterm infants (32 weeks gestational age or younger) (N = 36) who underwent structural MRI and diffusion tensor imaging serially at four time points - before 32, 32, 38, and 52 weeks postmenstrual age. We divided the corpus callosum into six subregions, performed probabilistic tractography, and used linear mixed effects models to evaluate the influence of antecedent clinical factors on its microstructural growth trajectory. The genu and splenium demonstrated the most rapid developmental maturation, exhibited by a steep increase in fractional anisotropy. We identified several factors that favored greater corpus callosum microstructural development, including advancing postmenstrual age, higher birth weight, and college level or higher maternal education. Bronchopulmonary dysplasia, low 5-minute Apgar scores, caffeine therapy/apnea of prematurity and male sex were associated with reduced corpus callosum microstructural integrity/development over the first six months after very preterm birth. We identified a unique postnatal microstructural growth trajectory and associated clinical factor profile for each of the six corpus callosum subregions that is consistent with the heterogeneous functional role of these white matter subregions.
format Online
Article
Text
id pubmed-5954149
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-59541492018-05-21 Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants Teli, Radhika Hay, Margaret Hershey, Alexa Kumar, Manoj Yin, Han Parikh, Nehal A. Sci Rep Article Our objectives were to define the microstructural developmental trajectory of six corpus callosum subregions and identify perinatal clinical factors that influence early development of these subregions in very preterm infants. We performed a longitudinal cohort study of very preterm infants (32 weeks gestational age or younger) (N = 36) who underwent structural MRI and diffusion tensor imaging serially at four time points - before 32, 32, 38, and 52 weeks postmenstrual age. We divided the corpus callosum into six subregions, performed probabilistic tractography, and used linear mixed effects models to evaluate the influence of antecedent clinical factors on its microstructural growth trajectory. The genu and splenium demonstrated the most rapid developmental maturation, exhibited by a steep increase in fractional anisotropy. We identified several factors that favored greater corpus callosum microstructural development, including advancing postmenstrual age, higher birth weight, and college level or higher maternal education. Bronchopulmonary dysplasia, low 5-minute Apgar scores, caffeine therapy/apnea of prematurity and male sex were associated with reduced corpus callosum microstructural integrity/development over the first six months after very preterm birth. We identified a unique postnatal microstructural growth trajectory and associated clinical factor profile for each of the six corpus callosum subregions that is consistent with the heterogeneous functional role of these white matter subregions. Nature Publishing Group UK 2018-05-15 /pmc/articles/PMC5954149/ /pubmed/29765059 http://dx.doi.org/10.1038/s41598-018-25245-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Teli, Radhika
Hay, Margaret
Hershey, Alexa
Kumar, Manoj
Yin, Han
Parikh, Nehal A.
Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants
title Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants
title_full Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants
title_fullStr Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants
title_full_unstemmed Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants
title_short Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants
title_sort postnatal microstructural developmental trajectory of corpus callosum subregions and relationship to clinical factors in very preterm infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954149/
https://www.ncbi.nlm.nih.gov/pubmed/29765059
http://dx.doi.org/10.1038/s41598-018-25245-7
work_keys_str_mv AT teliradhika postnatalmicrostructuraldevelopmentaltrajectoryofcorpuscallosumsubregionsandrelationshiptoclinicalfactorsinverypreterminfants
AT haymargaret postnatalmicrostructuraldevelopmentaltrajectoryofcorpuscallosumsubregionsandrelationshiptoclinicalfactorsinverypreterminfants
AT hersheyalexa postnatalmicrostructuraldevelopmentaltrajectoryofcorpuscallosumsubregionsandrelationshiptoclinicalfactorsinverypreterminfants
AT kumarmanoj postnatalmicrostructuraldevelopmentaltrajectoryofcorpuscallosumsubregionsandrelationshiptoclinicalfactorsinverypreterminfants
AT yinhan postnatalmicrostructuraldevelopmentaltrajectoryofcorpuscallosumsubregionsandrelationshiptoclinicalfactorsinverypreterminfants
AT parikhnehala postnatalmicrostructuraldevelopmentaltrajectoryofcorpuscallosumsubregionsandrelationshiptoclinicalfactorsinverypreterminfants