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AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms

Autophagy maintains metabolism in response to starvation, but each nutrient is sensed distinctly. Amino acid deficiency suppresses mechanistic target of rapamycin complex 1 (MTORC1), while glucose deficiency promotes AMP-activated protein kinase (AMPK). The MTORC1 and AMPK signaling pathways converg...

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Detalles Bibliográficos
Autores principales:	Nwadike, Chinwendu, Williamson, Leon E., Gallagher, Laura E., Guan, Jun-Lin, Chan, Edmond Y. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954193/ https://www.ncbi.nlm.nih.gov/pubmed/29507183 http://dx.doi.org/10.1128/MCB.00023-18

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