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Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques

BACKGROUND & OBJECTIVE: Leptin facilitates onset of puberty by impact on hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is un...

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Autores principales: Rehman, Rehana, Jamil, Zehra, Khalid, Aqsa, Fatima, Syeda Sadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954376/
https://www.ncbi.nlm.nih.gov/pubmed/29805405
http://dx.doi.org/10.12669/pjms.342.14078
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author Rehman, Rehana
Jamil, Zehra
Khalid, Aqsa
Fatima, Syeda Sadia
author_facet Rehman, Rehana
Jamil, Zehra
Khalid, Aqsa
Fatima, Syeda Sadia
author_sort Rehman, Rehana
collection PubMed
description BACKGROUND & OBJECTIVE: Leptin facilitates onset of puberty by impact on hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify Kisspeptin-Leptin association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females. METHODS: A cross sectional study was carried from August 2014 till May 2016 after receiving ethical approval at Australian Concept Infertility Medical Centre, and Aga Khan University. The study group comprised of females with an age range of 25-37 year who had duration of unexplained infertility for more than two years. They were grouped as; underweight (<18 kg/m(2)), normal weight (18-22.9 kg/m(2)), overweight 23-24.99 kg/m(2) and obese (>25 kg/m(2)). Kisspeptin and Leptin levels were measured by enzyme linked immune sorbent assay before down regulation of ovaries and initiation of treatment protocol of ART. Failure of procedure was detected by beta human chorionic gonadotropin <25mIU/ml (non-pregnant) whereas females with levels >25mIU/ml and cardiac activity on trans-vaginal scan were declared pregnant. RESULTS: Highest Kisspeptin and Leptin levels were seen in normal weight group (374.80 ± 185.08ng/L; 12.78 ± 6.8 pg/ml) respectively, yet the highest number of clinical pregnancy was observed in overweight group (42%).A strong correlation of Kisspeptin with Leptin (r=0.794, p=0.001) was observed in the overweight females. CONCLUSION: Leptin-Kisspeptin-fertility link is expressed by maximum number of clinical pregnancies in the female group that showed strongest relationship between serum Leptin and Kisspeptin levels, irrespective of their BMI.
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spelling pubmed-59543762018-05-25 Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques Rehman, Rehana Jamil, Zehra Khalid, Aqsa Fatima, Syeda Sadia Pak J Med Sci Original Article BACKGROUND & OBJECTIVE: Leptin facilitates onset of puberty by impact on hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify Kisspeptin-Leptin association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females. METHODS: A cross sectional study was carried from August 2014 till May 2016 after receiving ethical approval at Australian Concept Infertility Medical Centre, and Aga Khan University. The study group comprised of females with an age range of 25-37 year who had duration of unexplained infertility for more than two years. They were grouped as; underweight (<18 kg/m(2)), normal weight (18-22.9 kg/m(2)), overweight 23-24.99 kg/m(2) and obese (>25 kg/m(2)). Kisspeptin and Leptin levels were measured by enzyme linked immune sorbent assay before down regulation of ovaries and initiation of treatment protocol of ART. Failure of procedure was detected by beta human chorionic gonadotropin <25mIU/ml (non-pregnant) whereas females with levels >25mIU/ml and cardiac activity on trans-vaginal scan were declared pregnant. RESULTS: Highest Kisspeptin and Leptin levels were seen in normal weight group (374.80 ± 185.08ng/L; 12.78 ± 6.8 pg/ml) respectively, yet the highest number of clinical pregnancy was observed in overweight group (42%).A strong correlation of Kisspeptin with Leptin (r=0.794, p=0.001) was observed in the overweight females. CONCLUSION: Leptin-Kisspeptin-fertility link is expressed by maximum number of clinical pregnancies in the female group that showed strongest relationship between serum Leptin and Kisspeptin levels, irrespective of their BMI. Professional Medical Publications 2018 /pmc/articles/PMC5954376/ /pubmed/29805405 http://dx.doi.org/10.12669/pjms.342.14078 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rehman, Rehana
Jamil, Zehra
Khalid, Aqsa
Fatima, Syeda Sadia
Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques
title Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques
title_full Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques
title_fullStr Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques
title_full_unstemmed Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques
title_short Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques
title_sort cross talk between serum kisspeptin-leptin during assisted reproduction techniques
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954376/
https://www.ncbi.nlm.nih.gov/pubmed/29805405
http://dx.doi.org/10.12669/pjms.342.14078
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