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Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?
OBJECTIVE: The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED). METHODS: This was a prospective, observat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954390/ https://www.ncbi.nlm.nih.gov/pubmed/29805419 http://dx.doi.org/10.12669/pjms.342.13815 |
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author | Karacabey, Sinan Sanri, Erkman Yalcinli, Sercan Akoglu, Haldun |
author_facet | Karacabey, Sinan Sanri, Erkman Yalcinli, Sercan Akoglu, Haldun |
author_sort | Karacabey, Sinan |
collection | PubMed |
description | OBJECTIVE: The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED). METHODS: This was a prospective, observational, cross-sectional study. All patients who presented to the ED with a headache fulfilling the inclusion criteria were enrolled. All patients were treated by the attending emergency physicians in their daily routine. If an IV treatment in the ED was found indicated by the EP, they selected one of the options in the written departmental migraine treatment protocol. RESULTS: During the study period, 54 patients met the inclusion criteria. The median change in the pain score was significantly different among treatment options (p<0.0001). The median pain score change at the end of the 30 minutes for treatment groups were 7.5 mm (IQR: 7.0-8.0), 5.0 mm (IQR: 4.75-7.0), and 7.0 mm (IQR: 6.0-7.25), respectively (p=0.0002). All three groups were found to be significantly different from each other in the post-hoc analysis. CONCLUSION: All drugs compared in this study are effective in the relief of migraine headache. However, IV dexketoprofen seems to be faster and more effective than metoclopramide and ibuprofen. |
format | Online Article Text |
id | pubmed-5954390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-59543902018-05-25 Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide? Karacabey, Sinan Sanri, Erkman Yalcinli, Sercan Akoglu, Haldun Pak J Med Sci Original Article OBJECTIVE: The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED). METHODS: This was a prospective, observational, cross-sectional study. All patients who presented to the ED with a headache fulfilling the inclusion criteria were enrolled. All patients were treated by the attending emergency physicians in their daily routine. If an IV treatment in the ED was found indicated by the EP, they selected one of the options in the written departmental migraine treatment protocol. RESULTS: During the study period, 54 patients met the inclusion criteria. The median change in the pain score was significantly different among treatment options (p<0.0001). The median pain score change at the end of the 30 minutes for treatment groups were 7.5 mm (IQR: 7.0-8.0), 5.0 mm (IQR: 4.75-7.0), and 7.0 mm (IQR: 6.0-7.25), respectively (p=0.0002). All three groups were found to be significantly different from each other in the post-hoc analysis. CONCLUSION: All drugs compared in this study are effective in the relief of migraine headache. However, IV dexketoprofen seems to be faster and more effective than metoclopramide and ibuprofen. Professional Medical Publications 2018 /pmc/articles/PMC5954390/ /pubmed/29805419 http://dx.doi.org/10.12669/pjms.342.13815 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Karacabey, Sinan Sanri, Erkman Yalcinli, Sercan Akoglu, Haldun Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide? |
title | Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide? |
title_full | Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide? |
title_fullStr | Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide? |
title_full_unstemmed | Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide? |
title_short | Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide? |
title_sort | which is more effective for the treatment of acute migraine attack: dexketoprofen, ibuprofen or metoclopramide? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954390/ https://www.ncbi.nlm.nih.gov/pubmed/29805419 http://dx.doi.org/10.12669/pjms.342.13815 |
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