Cargando…

Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?

OBJECTIVE: The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED). METHODS: This was a prospective, observat...

Descripción completa

Detalles Bibliográficos
Autores principales: Karacabey, Sinan, Sanri, Erkman, Yalcinli, Sercan, Akoglu, Haldun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954390/
https://www.ncbi.nlm.nih.gov/pubmed/29805419
http://dx.doi.org/10.12669/pjms.342.13815
_version_ 1783323512095637504
author Karacabey, Sinan
Sanri, Erkman
Yalcinli, Sercan
Akoglu, Haldun
author_facet Karacabey, Sinan
Sanri, Erkman
Yalcinli, Sercan
Akoglu, Haldun
author_sort Karacabey, Sinan
collection PubMed
description OBJECTIVE: The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED). METHODS: This was a prospective, observational, cross-sectional study. All patients who presented to the ED with a headache fulfilling the inclusion criteria were enrolled. All patients were treated by the attending emergency physicians in their daily routine. If an IV treatment in the ED was found indicated by the EP, they selected one of the options in the written departmental migraine treatment protocol. RESULTS: During the study period, 54 patients met the inclusion criteria. The median change in the pain score was significantly different among treatment options (p<0.0001). The median pain score change at the end of the 30 minutes for treatment groups were 7.5 mm (IQR: 7.0-8.0), 5.0 mm (IQR: 4.75-7.0), and 7.0 mm (IQR: 6.0-7.25), respectively (p=0.0002). All three groups were found to be significantly different from each other in the post-hoc analysis. CONCLUSION: All drugs compared in this study are effective in the relief of migraine headache. However, IV dexketoprofen seems to be faster and more effective than metoclopramide and ibuprofen.
format Online
Article
Text
id pubmed-5954390
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Professional Medical Publications
record_format MEDLINE/PubMed
spelling pubmed-59543902018-05-25 Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide? Karacabey, Sinan Sanri, Erkman Yalcinli, Sercan Akoglu, Haldun Pak J Med Sci Original Article OBJECTIVE: The aim of this study was head-to-head comparison of the efficacy and rate of adverse events of metoclopramide, ibuprofen and dexketoprofen for the acute treatment of migraine attack in the real-life conditions of a busy emergency department (ED). METHODS: This was a prospective, observational, cross-sectional study. All patients who presented to the ED with a headache fulfilling the inclusion criteria were enrolled. All patients were treated by the attending emergency physicians in their daily routine. If an IV treatment in the ED was found indicated by the EP, they selected one of the options in the written departmental migraine treatment protocol. RESULTS: During the study period, 54 patients met the inclusion criteria. The median change in the pain score was significantly different among treatment options (p<0.0001). The median pain score change at the end of the 30 minutes for treatment groups were 7.5 mm (IQR: 7.0-8.0), 5.0 mm (IQR: 4.75-7.0), and 7.0 mm (IQR: 6.0-7.25), respectively (p=0.0002). All three groups were found to be significantly different from each other in the post-hoc analysis. CONCLUSION: All drugs compared in this study are effective in the relief of migraine headache. However, IV dexketoprofen seems to be faster and more effective than metoclopramide and ibuprofen. Professional Medical Publications 2018 /pmc/articles/PMC5954390/ /pubmed/29805419 http://dx.doi.org/10.12669/pjms.342.13815 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Karacabey, Sinan
Sanri, Erkman
Yalcinli, Sercan
Akoglu, Haldun
Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?
title Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?
title_full Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?
title_fullStr Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?
title_full_unstemmed Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?
title_short Which is more effective for the treatment of Acute Migraine Attack: Dexketoprofen, Ibuprofen or Metoclopramide?
title_sort which is more effective for the treatment of acute migraine attack: dexketoprofen, ibuprofen or metoclopramide?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954390/
https://www.ncbi.nlm.nih.gov/pubmed/29805419
http://dx.doi.org/10.12669/pjms.342.13815
work_keys_str_mv AT karacabeysinan whichismoreeffectiveforthetreatmentofacutemigraineattackdexketoprofenibuprofenormetoclopramide
AT sanrierkman whichismoreeffectiveforthetreatmentofacutemigraineattackdexketoprofenibuprofenormetoclopramide
AT yalcinlisercan whichismoreeffectiveforthetreatmentofacutemigraineattackdexketoprofenibuprofenormetoclopramide
AT akogluhaldun whichismoreeffectiveforthetreatmentofacutemigraineattackdexketoprofenibuprofenormetoclopramide