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The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events
The matrix metalloproteinases are a family of peptidase enzymes responsible for the degradation of extracellular matrix (ECM). Alterations in the structure and composition of the ECM play a key role in the atherogenic process. Recent data suggest the important role of MMPs in the development of athe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Communications and Publications Division (CPD) of the IFCC
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954426/ https://www.ncbi.nlm.nih.gov/pubmed/29795714 |
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author | Magdalena, Krintus Magdalena, Kuligowska Grazyna, Sypniewska |
author_facet | Magdalena, Krintus Magdalena, Kuligowska Grazyna, Sypniewska |
author_sort | Magdalena, Krintus |
collection | PubMed |
description | The matrix metalloproteinases are a family of peptidase enzymes responsible for the degradation of extracellular matrix (ECM). Alterations in the structure and composition of the ECM play a key role in the atherogenic process. Recent data suggest the important role of MMPs in the development of atherosclerosis and future cardiovascular events. Expressed at low levels in normal tissue, MMPs are upregulated in remodeling processes. Matrix metalloproteinase-3 (MMP-3) is present in atherosclerotic plaques and acts in the degradation of the fibrous cap of the atheroma. Many clinical studies reported that increased MMP-3 level and also the gene polymorphism of MMP were the independent cardiovascular risk factors. MMPs represent an attractive target to prevent matrix degradation, atherosclerosis and possible cardiovascular events. |
format | Online Article Text |
id | pubmed-5954426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Communications and Publications Division (CPD) of the IFCC |
record_format | MEDLINE/PubMed |
spelling | pubmed-59544262018-05-23 The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events Magdalena, Krintus Magdalena, Kuligowska Grazyna, Sypniewska EJIFCC Research Article The matrix metalloproteinases are a family of peptidase enzymes responsible for the degradation of extracellular matrix (ECM). Alterations in the structure and composition of the ECM play a key role in the atherogenic process. Recent data suggest the important role of MMPs in the development of atherosclerosis and future cardiovascular events. Expressed at low levels in normal tissue, MMPs are upregulated in remodeling processes. Matrix metalloproteinase-3 (MMP-3) is present in atherosclerotic plaques and acts in the degradation of the fibrous cap of the atheroma. Many clinical studies reported that increased MMP-3 level and also the gene polymorphism of MMP were the independent cardiovascular risk factors. MMPs represent an attractive target to prevent matrix degradation, atherosclerosis and possible cardiovascular events. The Communications and Publications Division (CPD) of the IFCC 2006-03-20 /pmc/articles/PMC5954426/ /pubmed/29795714 Text en Copyright © 2006 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Magdalena, Krintus Magdalena, Kuligowska Grazyna, Sypniewska The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events |
title | The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events |
title_full | The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events |
title_fullStr | The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events |
title_full_unstemmed | The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events |
title_short | The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and Cardiovascular Events |
title_sort | role of matrix metalloproteinase-3 in the development of atherosclerosis and cardiovascular events |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954426/ https://www.ncbi.nlm.nih.gov/pubmed/29795714 |
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