Pure erythroid leukemia in a polymyositis patient treated with azathioprine

Acute erythroid leukemia, also known as acute myeloid leukemia-M6, may be associated with previous chemotherapy or immunosuppressive therapy. For 10 years, a 69-year-old Japanese female patient with pure erythroid leukemia (or acute myeloid leukemia-M6b) was treated for polymyositis with 50–100 mg/d...

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Autores principales: Imataki, Osamu, Takeuchi, Akihiro, Uchida, Shumpei, Yokokura, Shigeyuki, Uemura, Makiko, Kadowaki, Norimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954579/
https://www.ncbi.nlm.nih.gov/pubmed/29785257
http://dx.doi.org/10.1177/2036361318773847
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author Imataki, Osamu
Takeuchi, Akihiro
Uchida, Shumpei
Yokokura, Shigeyuki
Uemura, Makiko
Kadowaki, Norimitsu
author_facet Imataki, Osamu
Takeuchi, Akihiro
Uchida, Shumpei
Yokokura, Shigeyuki
Uemura, Makiko
Kadowaki, Norimitsu
author_sort Imataki, Osamu
collection PubMed
description Acute erythroid leukemia, also known as acute myeloid leukemia-M6, may be associated with previous chemotherapy or immunosuppressive therapy. For 10 years, a 69-year-old Japanese female patient with pure erythroid leukemia (or acute myeloid leukemia-M6b) was treated for polymyositis with 50–100 mg/day azathioprine. She complained of dyspnea with low-grade fever and was diagnosed as having pure erythroid leukemia. Chromosomal analysis revealed a complex karyotype abnormality, with the deletion of 5q, -6, -7 and addition of 11q13. No morphological myelodysplastic changes were observed in her bone marrow cells. In this study, azathioprine accumulation was considered to be associated with the patient’s leukemogenesis.
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spelling pubmed-59545792018-05-21 Pure erythroid leukemia in a polymyositis patient treated with azathioprine Imataki, Osamu Takeuchi, Akihiro Uchida, Shumpei Yokokura, Shigeyuki Uemura, Makiko Kadowaki, Norimitsu Rare Tumors Case Report Acute erythroid leukemia, also known as acute myeloid leukemia-M6, may be associated with previous chemotherapy or immunosuppressive therapy. For 10 years, a 69-year-old Japanese female patient with pure erythroid leukemia (or acute myeloid leukemia-M6b) was treated for polymyositis with 50–100 mg/day azathioprine. She complained of dyspnea with low-grade fever and was diagnosed as having pure erythroid leukemia. Chromosomal analysis revealed a complex karyotype abnormality, with the deletion of 5q, -6, -7 and addition of 11q13. No morphological myelodysplastic changes were observed in her bone marrow cells. In this study, azathioprine accumulation was considered to be associated with the patient’s leukemogenesis. SAGE Publications 2018-05-14 /pmc/articles/PMC5954579/ /pubmed/29785257 http://dx.doi.org/10.1177/2036361318773847 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Imataki, Osamu
Takeuchi, Akihiro
Uchida, Shumpei
Yokokura, Shigeyuki
Uemura, Makiko
Kadowaki, Norimitsu
Pure erythroid leukemia in a polymyositis patient treated with azathioprine
title Pure erythroid leukemia in a polymyositis patient treated with azathioprine
title_full Pure erythroid leukemia in a polymyositis patient treated with azathioprine
title_fullStr Pure erythroid leukemia in a polymyositis patient treated with azathioprine
title_full_unstemmed Pure erythroid leukemia in a polymyositis patient treated with azathioprine
title_short Pure erythroid leukemia in a polymyositis patient treated with azathioprine
title_sort pure erythroid leukemia in a polymyositis patient treated with azathioprine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954579/
https://www.ncbi.nlm.nih.gov/pubmed/29785257
http://dx.doi.org/10.1177/2036361318773847
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