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Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway

BACKGROUND: Topotecan (TP) is an anticancer drug acting as topoisomerase I inhibitor that is used in the treatment of many types of cancers including leukemia, but it has significant side effects. Andrographolide, a compound extracted from Andrographis paniculata, was recently proven to inhibit the...

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Detalles Bibliográficos
Autores principales:	Hodroj, Mohammad Hassan, Jardaly, Achraf, Abi Raad, Sarah, Zouein, Annalise, Rizk, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955015/ https://www.ncbi.nlm.nih.gov/pubmed/29785137 http://dx.doi.org/10.2147/CMAR.S160924

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