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Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?

OBJECTIVE: The efficacy of additional cores from cancer-suspicious lesions by transrectal ultrasound (TRUS) for the detection of prostate cancer (PCa) was assessed. MATERIALS AND METHODS: Data were collected from 4144 men who underwent systematic 12-core biopsy with no cancer-suspicious lesions (Gro...

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Autores principales: Jo, Jung Ki, Hong, Sung Kyu, Byun, Seok-Soo, Lee, Sang Eun, Jeong, Seong Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955022/
https://www.ncbi.nlm.nih.gov/pubmed/29785140
http://dx.doi.org/10.2147/CMAR.S149785
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author Jo, Jung Ki
Hong, Sung Kyu
Byun, Seok-Soo
Lee, Sang Eun
Jeong, Seong Jin
author_facet Jo, Jung Ki
Hong, Sung Kyu
Byun, Seok-Soo
Lee, Sang Eun
Jeong, Seong Jin
author_sort Jo, Jung Ki
collection PubMed
description OBJECTIVE: The efficacy of additional cores from cancer-suspicious lesions by transrectal ultrasound (TRUS) for the detection of prostate cancer (PCa) was assessed. MATERIALS AND METHODS: Data were collected from 4144 men who underwent systematic 12-core biopsy with no cancer-suspicious lesions (Group A: 3256 cases) or 13- or more-core (systematic 12 core + additional cores) biopsy with cancer-suspicious lesions (Group B: 888 cases) on TRUS-guided biopsy. The effect of additional biopsy cores on the cancer detection rate was investigated. RESULTS: PCa was detected in 1006 (30.9%) cases in Group A and 485 (54.6%) cases in Group B (p < 0.001). In 370/485 (76.3%) patients in Group B, cancer was detected from the additional cores from TRUS suspicious lesions. Logistic regression analysis showed that the number of biopsy cores was the most significant factor for cancer detection (hazards ratio: 2.6 [2.221–3.043], p < 0.001]. Additional core biopsies did not increase the detection rate of index tumors (p < 0.001). However, the Gleason score of index tumors was higher than that of systematic cores (p < 0.001). Kaplan–Meier analysis showed no significant differences in survival according to biopsy number and location of index tumors (log-rank test: p = 0.583, p = 0.165, respectively). CONCLUSION: Although additional core biopsies can increase the cancer detection rate, they do not increase the detection rate of index tumors. Biopsy core number and the location of index tumors had no effect on biochemical outcomes.
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spelling pubmed-59550222018-05-21 Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy? Jo, Jung Ki Hong, Sung Kyu Byun, Seok-Soo Lee, Sang Eun Jeong, Seong Jin Cancer Manag Res Original Research OBJECTIVE: The efficacy of additional cores from cancer-suspicious lesions by transrectal ultrasound (TRUS) for the detection of prostate cancer (PCa) was assessed. MATERIALS AND METHODS: Data were collected from 4144 men who underwent systematic 12-core biopsy with no cancer-suspicious lesions (Group A: 3256 cases) or 13- or more-core (systematic 12 core + additional cores) biopsy with cancer-suspicious lesions (Group B: 888 cases) on TRUS-guided biopsy. The effect of additional biopsy cores on the cancer detection rate was investigated. RESULTS: PCa was detected in 1006 (30.9%) cases in Group A and 485 (54.6%) cases in Group B (p < 0.001). In 370/485 (76.3%) patients in Group B, cancer was detected from the additional cores from TRUS suspicious lesions. Logistic regression analysis showed that the number of biopsy cores was the most significant factor for cancer detection (hazards ratio: 2.6 [2.221–3.043], p < 0.001]. Additional core biopsies did not increase the detection rate of index tumors (p < 0.001). However, the Gleason score of index tumors was higher than that of systematic cores (p < 0.001). Kaplan–Meier analysis showed no significant differences in survival according to biopsy number and location of index tumors (log-rank test: p = 0.583, p = 0.165, respectively). CONCLUSION: Although additional core biopsies can increase the cancer detection rate, they do not increase the detection rate of index tumors. Biopsy core number and the location of index tumors had no effect on biochemical outcomes. Dove Medical Press 2018-05-10 /pmc/articles/PMC5955022/ /pubmed/29785140 http://dx.doi.org/10.2147/CMAR.S149785 Text en © 2018 Jo et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Jo, Jung Ki
Hong, Sung Kyu
Byun, Seok-Soo
Lee, Sang Eun
Jeong, Seong Jin
Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?
title Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?
title_full Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?
title_fullStr Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?
title_full_unstemmed Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?
title_short Do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?
title_sort do additional cores from cancer-suspicious lesions on transrectal ultrasound improve prostate cancer detection including index tumors over 12-core systematic biopsy?
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955022/
https://www.ncbi.nlm.nih.gov/pubmed/29785140
http://dx.doi.org/10.2147/CMAR.S149785
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