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Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis

BACKGROUND: The incidence of acral lentiginous melanoma (ALM) in the white population is low. Dermoscopy enhances diagnosis of ALM; however, diagnostic accuracy may sometimes be poor due to the considerable proportion of amelanotic ALM variants. OBJECTIVES: To calculate the proportion of ALM among a...

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Autores principales: Ozdemir, Fezal, Errico, Micol A., Yaman, Banu, Karaarslan, Isil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Derm101.com 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955083/
https://www.ncbi.nlm.nih.gov/pubmed/29785333
http://dx.doi.org/10.5826/dpc.0802a14
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author Ozdemir, Fezal
Errico, Micol A.
Yaman, Banu
Karaarslan, Isil
author_facet Ozdemir, Fezal
Errico, Micol A.
Yaman, Banu
Karaarslan, Isil
author_sort Ozdemir, Fezal
collection PubMed
description BACKGROUND: The incidence of acral lentiginous melanoma (ALM) in the white population is low. Dermoscopy enhances diagnosis of ALM; however, diagnostic accuracy may sometimes be poor due to the considerable proportion of amelanotic ALM variants. OBJECTIVES: To calculate the proportion of ALM among all melanoma subtypes and to determine the frequency of dermoscopic features of ALM in the Turkish population. METHODS: Out of 612 melanomas, there were 70 cases of ALM, of which 46 showed sufficient image quality for retrospective study of dermoscopic features. Data from patients and their lesions was classified according to clinical features and histopathologic parameters. The dermoscopic variables evaluated were based on pertinent literature on dermoscopy of acral melanocytic neoplasms. RESULTS: The prevalence of ALM among all melanoma subtypes was 11.4%. Parallel-ridge pattern (PRP) was detected in 60.8% of cases and irregular diffuse pigmentation (IDP) in 28.3%. The ALMs were amelanotic in 24%, showing an atypical vascular pattern in all cases; a new dermoscopic pattern, named “vascularized parallel-ridge pattern” (VPRP), was detected in 13% of ALMs. Irregular lines were observed in 81.8% of subungual melanomas and were often associated with a multicolored background. CONCLUSIONS: ALM has site-specific dermoscopic patterns, with PRP being the most prevalent pattern. The newly described VPRP pattern may be an additional clue for ALM diagnosis, especially in thin amelanotic melanomas.
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spelling pubmed-59550832018-05-21 Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis Ozdemir, Fezal Errico, Micol A. Yaman, Banu Karaarslan, Isil Dermatol Pract Concept Articles BACKGROUND: The incidence of acral lentiginous melanoma (ALM) in the white population is low. Dermoscopy enhances diagnosis of ALM; however, diagnostic accuracy may sometimes be poor due to the considerable proportion of amelanotic ALM variants. OBJECTIVES: To calculate the proportion of ALM among all melanoma subtypes and to determine the frequency of dermoscopic features of ALM in the Turkish population. METHODS: Out of 612 melanomas, there were 70 cases of ALM, of which 46 showed sufficient image quality for retrospective study of dermoscopic features. Data from patients and their lesions was classified according to clinical features and histopathologic parameters. The dermoscopic variables evaluated were based on pertinent literature on dermoscopy of acral melanocytic neoplasms. RESULTS: The prevalence of ALM among all melanoma subtypes was 11.4%. Parallel-ridge pattern (PRP) was detected in 60.8% of cases and irregular diffuse pigmentation (IDP) in 28.3%. The ALMs were amelanotic in 24%, showing an atypical vascular pattern in all cases; a new dermoscopic pattern, named “vascularized parallel-ridge pattern” (VPRP), was detected in 13% of ALMs. Irregular lines were observed in 81.8% of subungual melanomas and were often associated with a multicolored background. CONCLUSIONS: ALM has site-specific dermoscopic patterns, with PRP being the most prevalent pattern. The newly described VPRP pattern may be an additional clue for ALM diagnosis, especially in thin amelanotic melanomas. Derm101.com 2018-04-30 /pmc/articles/PMC5955083/ /pubmed/29785333 http://dx.doi.org/10.5826/dpc.0802a14 Text en ©2018 Ozdemir et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Ozdemir, Fezal
Errico, Micol A.
Yaman, Banu
Karaarslan, Isil
Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis
title Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis
title_full Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis
title_fullStr Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis
title_full_unstemmed Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis
title_short Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis
title_sort acral lentiginous melanoma in the turkish population and a new dermoscopic clue for the diagnosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955083/
https://www.ncbi.nlm.nih.gov/pubmed/29785333
http://dx.doi.org/10.5826/dpc.0802a14
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