Cargando…

A high LDH to absolute lymphocyte count ratio in patients with DLBCL predicts for a poor intratumoral immune response and inferior survival

PURPOSE: To test the utility of the circulating Lactate Dehydrogenase (LDH) to absolute lymphocyte count (ALC) ratio (LAR) to predict outcome to conventional first-line chemo-immunotherapy in Diffuse Large B-cell Lymphoma (DLBCL), and investigate its correlation to the tumour immune microenvironment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keane, Colm, Tobin, Joshua, Talaulikar, Dipti, Green, Michael, Crooks, Pauline, Jain, Sanjiv, Gandhi, Maher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955090/ https://www.ncbi.nlm.nih.gov/pubmed/29805761 http://dx.doi.org/10.18632/oncotarget.25306

Ejemplares similares

The tumour microenvironment is immuno‐tolerogenic and a principal determinant of patient outcome in EBV‐positive diffuse large B‐cell lymphoma
por: Keane, Colm, et al.
Publicado: (2019)

Circulating cell-free miR-494 and miR-21 are disease response biomarkers associated with interim-positron emission tomography response in patients with diffuse large B-cell lymphoma
por: Cui, Qingyan, et al.
Publicado: (2018)

Low Multiplication Value of Absolute Monocyte Count and Absolute Lymphocyte Count at Diagnosis May Predict Poor Prognosis in Neuroblastoma
por: Tamura, Akihiro, et al.
Publicado: (2020)

High proportion of anergic B cells in the bone marrow defined phenotypically by CD21(−/low)/CD38- expression predicts poor survival in diffuse large B cell lymphoma
por: Rijal, Sewa, et al.
Publicado: (2020)

CD4 T cells: the complicated key to unlocking the immune environment of classical Hodgkin lymphoma
por: Gandhi, Maher K., et al.
Publicado: (2022)

Expanding the bacterial origins of nodular lymphocyte-predominant Hodgkin lymphoma
por: Gandhi, Maher K., et al.
Publicado: (2023)

Genomic profiling of CD20 negative diffuse large B cell lymphoma identifies targetable mutations: A case report
por: Maqbool, M. Gohar, et al.
Publicado: (2020)

Value of the use of absolute lymphocyte as surrogate for CD4 count in resource poor situations
por: Adegbamigbe, Oluwafemi Johanson, et al.
Publicado: (2014)

Pretreatment Liver Injury Predicts Poor Prognosis of DLBCL Patients
por: Shi, Qing, et al.
Publicado: (2017)

Prognostic Significance of Absolute Lymphocyte Count/Absolute Monocyte Count Ratio at Diagnosis in Patients with Multiple Myeloma
por: Shin, Su-Jin, et al.
Publicado: (2013)

High Pretreatment LDH Predicts Poor Prognosis in Hypopharyngeal Cancer
por: Wu, Jialing, et al.
Publicado: (2021)

Progression of Disease Within 24 Months in Follicular Lymphoma Is Associated With Reduced Intratumoral Immune Infiltration
por: Tobin, Joshua W.D., et al.
Publicado: (2019)

HBV-associated DLBCL of poor prognosis: advance in pathogenesis, immunity and therapy
por: Wan, Xin, et al.
Publicado: (2023)

Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach
por: Wagner, Marcus, et al.
Publicado: (2019)

The Immunology of DLBCL
por: Takahara, Taishi, et al.
Publicado: (2023)

Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer
por: Huang, Xiang, et al.
Publicado: (2022)

Biology and therapy of primary mediastinal B‐cell lymphoma: current status and future directions
por: Lees, Charlotte, et al.
Publicado: (2019)

CD5 and CD43 Expression are Associate with Poor Prognosis in DLBCL Patients
por: Huang, Hui, et al.
Publicado: (2018)

Utility of the Ratio between Lactate Dehydrogenase (LDH) Activity and Total Nucleated Cell Counts in Effusions (LDH/TNCC Ratio) for the Diagnosis of Feline Infectious Peritonitis (FIP)
por: Romanelli, Pierpaolo, et al.
Publicado: (2022)

Comparison of MHG and DZsig reveals shared biology and a core overlap group with inferior prognosis in DLBCL
por: Davies, John R., et al.
Publicado: (2023)

Postoperative Low Absolute Lymphocyte Counts may Predict Poor Outcomes of Hepatocellular Carcinoma After Liver Resection
por: Wang, Ming, et al.
Publicado: (2016)

Check'-ing DLBCL
por: Salaverria, Itziar, et al.
Publicado: (2015)

DLBCL Coast to Coast
por: Tesio, Melania
Publicado: (2018)

GOALs in relapsed DLBCL
por: Rösler, Wiebke, et al.
Publicado: (2022)

PB1744: THE RATIO OF ABSOLUTE LYMPHOCYTE COUNT AT INTERIM OF THERAPY TO ABSOLUTE LYMPHOCYTE COUNT AT DIAGNOSIS PREDICTS SURVIVAL IN ACUTE LYMPHOBLASTIC LEUKEMIA
por: Faiza, Talbi, et al.
Publicado: (2023)

Intratumoral T‐cell receptor repertoire is predictive of interim PET scan results in patients with diffuse large B‐cell lymphoma treated with rituximab/cyclophosphamide/doxorubicin/prednisolone/vincristine (R‐CHOP) chemoimmunotherapy
por: Shanavas, Mohamed, et al.
Publicado: (2021)

Analysis of absolute lymphocyte count in patients with COVID-19
por: Illg, Zachary, et al.
Publicado: (2021)

TRUmiCount: correctly counting absolute numbers of molecules using unique molecular identifiers
por: Pflug, Florian G, et al.
Publicado: (2018)

Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma
por: Li, Guo, et al.
Publicado: (2012)

Special Issue: Layered Double Hydroxides (LDH) and LDH-Based Hybrid Composites
por: Matusik, Jakub
Publicado: (2021)

Low Absolute Lymphocyte Counts in the Peripheral Blood Predict Inferior Survival and Improve the International Prognostic Index in Testicular Diffuse Large B-Cell Lymphoma
por: Vähämurto, Pauli, et al.
Publicado: (2020)

Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis
por: Gambichler, T, et al.
Publicado: (2010)

Counting the Photons: Determining the Absolute Storage Capacity of Persistent Phosphors
por: Van der Heggen, David, et al.
Publicado: (2017)

Absolute lymphocyte and neutrophil counts in neonatal ischemic brain injury
por: Povroznik, Jessica M, et al.
Publicado: (2018)

Factors of emotional distress in lymphoma: A systematic review
por: Tan, Kai Ping, et al.
Publicado: (2023)

Avelumab in Combination Regimens for Relapsed/Refractory DLBCL: Results from the Phase Ib JAVELIN DLBCL Study
por: Hawkes, Eliza A., et al.
Publicado: (2021)

DLBCL-Morph: Morphological features computed using deep learning for an annotated digital DLBCL image set
por: Vrabac, Damir, et al.
Publicado: (2021)

Serum LDH levels may predict poor neurological outcome after aneurysmal subarachnoid hemorrhage
por: Cavalli, Irene, et al.
Publicado: (2023)

Validating lactate dehydrogenase (LDH) as a component of the PLASMIC predictive tool (PLASMIC-LDH)
por: Liam, Christopher Chin Keong, et al.
Publicado: (2023)

A high absolute lymphocyte count predicts a poor prognosis in HER-2- positive breast cancer patients treated with trastuzumab
por: Hong, Jin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hm9eu3s4vj0524g0isjqs0opkl