Cargando…

Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe(3)O(4) carbon dots with graphitic black phosphorus quantum dots

BACKGROUND: Recently, combined photodynamic therapy (PDT) and photothermal therapy (PTT) has become a desired treatment for cancer. However, the development of economic, high-efficiency, and safe photosensitizers/photothermal agents remains a significant challenge. METHODS: A novel nanocomposite has...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ming, Wang, Wentao, Cui, Yingjun, Zhou, Ninglin, Shen, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955383/
https://www.ncbi.nlm.nih.gov/pubmed/29785107
http://dx.doi.org/10.2147/IJN.S156434
_version_ 1783323703258382336
author Zhang, Ming
Wang, Wentao
Cui, Yingjun
Zhou, Ninglin
Shen, Jian
author_facet Zhang, Ming
Wang, Wentao
Cui, Yingjun
Zhou, Ninglin
Shen, Jian
author_sort Zhang, Ming
collection PubMed
description BACKGROUND: Recently, combined photodynamic therapy (PDT) and photothermal therapy (PTT) has become a desired treatment for cancer. However, the development of economic, high-efficiency, and safe photosensitizers/photothermal agents remains a significant challenge. METHODS: A novel nanocomposite has been developed via the assembly of iron oxide carbon dot (Fe(3)O(4)-CDs) nanoparticles and black phosphorus quantum dots (genipin [GP]-polyglutamic acid [PGA]-Fe(3)O(4)-CDs@BPQDs), and this nanocomposite shows a broad light-absorption band and a photodegradable character. RESULTS: In vitro and in vivo assays indicated that GP-PGA-Fe(3)O(4)-CDs@BPQDs were highly biocompatible and exhibited excellent tumor-inhibition efficacy, due to the synergistic PTT and PDT via a near-infrared laser. Importantly, in vivo tumor magnetic resonance imaging (MRI) results illustrated that GP-PGA-Fe(3)O(4)-CDs@BPQDs can be specifically applied for enhanced T(2) MRI of tumors. This work presents the first combined application of a PDT and PTT effect deriving from BPQDs and MRI from Fe(3)O(4)-CDs, which may promote utilization of black BPQDs in biomedicine. CONCLUSION: As expected, GP-PGA-Fe(3)O(4)-CDs@BPQDs displayed a dramatically enhanced ability to destroy tumor cells, due to the synergistic combination of PTT and PDT.
format Online
Article
Text
id pubmed-5955383
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-59553832018-05-21 Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe(3)O(4) carbon dots with graphitic black phosphorus quantum dots Zhang, Ming Wang, Wentao Cui, Yingjun Zhou, Ninglin Shen, Jian Int J Nanomedicine Original Research BACKGROUND: Recently, combined photodynamic therapy (PDT) and photothermal therapy (PTT) has become a desired treatment for cancer. However, the development of economic, high-efficiency, and safe photosensitizers/photothermal agents remains a significant challenge. METHODS: A novel nanocomposite has been developed via the assembly of iron oxide carbon dot (Fe(3)O(4)-CDs) nanoparticles and black phosphorus quantum dots (genipin [GP]-polyglutamic acid [PGA]-Fe(3)O(4)-CDs@BPQDs), and this nanocomposite shows a broad light-absorption band and a photodegradable character. RESULTS: In vitro and in vivo assays indicated that GP-PGA-Fe(3)O(4)-CDs@BPQDs were highly biocompatible and exhibited excellent tumor-inhibition efficacy, due to the synergistic PTT and PDT via a near-infrared laser. Importantly, in vivo tumor magnetic resonance imaging (MRI) results illustrated that GP-PGA-Fe(3)O(4)-CDs@BPQDs can be specifically applied for enhanced T(2) MRI of tumors. This work presents the first combined application of a PDT and PTT effect deriving from BPQDs and MRI from Fe(3)O(4)-CDs, which may promote utilization of black BPQDs in biomedicine. CONCLUSION: As expected, GP-PGA-Fe(3)O(4)-CDs@BPQDs displayed a dramatically enhanced ability to destroy tumor cells, due to the synergistic combination of PTT and PDT. Dove Medical Press 2018-05-10 /pmc/articles/PMC5955383/ /pubmed/29785107 http://dx.doi.org/10.2147/IJN.S156434 Text en © 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhang, Ming
Wang, Wentao
Cui, Yingjun
Zhou, Ninglin
Shen, Jian
Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe(3)O(4) carbon dots with graphitic black phosphorus quantum dots
title Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe(3)O(4) carbon dots with graphitic black phosphorus quantum dots
title_full Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe(3)O(4) carbon dots with graphitic black phosphorus quantum dots
title_fullStr Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe(3)O(4) carbon dots with graphitic black phosphorus quantum dots
title_full_unstemmed Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe(3)O(4) carbon dots with graphitic black phosphorus quantum dots
title_short Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe(3)O(4) carbon dots with graphitic black phosphorus quantum dots
title_sort near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of fe(3)o(4) carbon dots with graphitic black phosphorus quantum dots
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955383/
https://www.ncbi.nlm.nih.gov/pubmed/29785107
http://dx.doi.org/10.2147/IJN.S156434
work_keys_str_mv AT zhangming nearinfraredlightmediatedphotodynamicphotothermaltherapynanoplatformbytheassemblyoffe3o4carbondotswithgraphiticblackphosphorusquantumdots
AT wangwentao nearinfraredlightmediatedphotodynamicphotothermaltherapynanoplatformbytheassemblyoffe3o4carbondotswithgraphiticblackphosphorusquantumdots
AT cuiyingjun nearinfraredlightmediatedphotodynamicphotothermaltherapynanoplatformbytheassemblyoffe3o4carbondotswithgraphiticblackphosphorusquantumdots
AT zhouninglin nearinfraredlightmediatedphotodynamicphotothermaltherapynanoplatformbytheassemblyoffe3o4carbondotswithgraphiticblackphosphorusquantumdots
AT shenjian nearinfraredlightmediatedphotodynamicphotothermaltherapynanoplatformbytheassemblyoffe3o4carbondotswithgraphiticblackphosphorusquantumdots