DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation

RHOA missense mutations exist specifically in diffuse type gastric cancers (DGC) and are considered one of the DGC driver genes, but it is not fully understood how RHOA mutations contribute to DGC development. Here we examined how RHOA mutations affect cancer cell survival and cell motility. We reve...

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Detalles Bibliográficos
Autores principales: Nishizawa, Takashi, Nakano, Kiyotaka, Harada, Aya, Kakiuchi, Miwako, Funahashi, Shin-Ichi, Suzuki, Masami, Ishikawa, Shumpei, Aburatani, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955407/
https://www.ncbi.nlm.nih.gov/pubmed/29796182
http://dx.doi.org/10.18632/oncotarget.25269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955407/
https://www.ncbi.nlm.nih.gov/pubmed/29796182
http://dx.doi.org/10.18632/oncotarget.25269

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