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Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma
We examined the usefulness of evaluating tumor size determined using preoperative magnetic resonance imaging (MRI) for prognosis in patients with endometrial carcinoma (EC). Patients (N = 184) with EC who underwent surgery at Shimane University Hospital between 1997 and 2013 were enrolled. We invest...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955431/ https://www.ncbi.nlm.nih.gov/pubmed/29796179 http://dx.doi.org/10.18632/oncotarget.25248 |
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author | Nakamura, Kohei Nakayama, Kentaro Ishikawa, Noriyoshi Minamoto, Toshiko Ishibashi, Tomoka Ohnishi, Kaori Yamashita, Hitomi Ono, Ruriko Sasamori, Hiroki Razia, Sultana Hossain, Mohammad Mahmud Kamrunnahar, Shanta Ishikawa, Masako Kyo, Satoru |
author_facet | Nakamura, Kohei Nakayama, Kentaro Ishikawa, Noriyoshi Minamoto, Toshiko Ishibashi, Tomoka Ohnishi, Kaori Yamashita, Hitomi Ono, Ruriko Sasamori, Hiroki Razia, Sultana Hossain, Mohammad Mahmud Kamrunnahar, Shanta Ishikawa, Masako Kyo, Satoru |
author_sort | Nakamura, Kohei |
collection | PubMed |
description | We examined the usefulness of evaluating tumor size determined using preoperative magnetic resonance imaging (MRI) for prognosis in patients with endometrial carcinoma (EC). Patients (N = 184) with EC who underwent surgery at Shimane University Hospital between 1997 and 2013 were enrolled. We investigated the association between the tumor size of EC assessed prior to surgery by MRI (anteroposterior [AP], transverse [TV], and craniocaudal [CC] diameters) and various clinical parameters including deep myometrial invasion and lymph node metastases. We subsequently examined the prognostic significance of tumor size in patients with EC. Survival analysis was performed using the Kaplan-Meier method, and prognostic factors were evaluated using the Cox’s proportional hazards regression model. Multivariate analysis identified increased AP diameter as an independent negative prognostic factor for overall survival (OS) (P = 0.037). A long AP diameter has prognostic value and the potential to be a predictive marker for surgical outcomes in patients with EC. Furthermore, AP diameter exhibited the greatest area under the curve (AUC) (0.727) for deep myometrial invasion, and CC diameter had the greatest AUC for lymph node metastases (0.854). Evaluation of tumor size parameters may aid in the identification of high-risk populations, which could improve treatment selection and patient outcomes. |
format | Online Article Text |
id | pubmed-5955431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-59554312018-05-24 Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma Nakamura, Kohei Nakayama, Kentaro Ishikawa, Noriyoshi Minamoto, Toshiko Ishibashi, Tomoka Ohnishi, Kaori Yamashita, Hitomi Ono, Ruriko Sasamori, Hiroki Razia, Sultana Hossain, Mohammad Mahmud Kamrunnahar, Shanta Ishikawa, Masako Kyo, Satoru Oncotarget Research Paper We examined the usefulness of evaluating tumor size determined using preoperative magnetic resonance imaging (MRI) for prognosis in patients with endometrial carcinoma (EC). Patients (N = 184) with EC who underwent surgery at Shimane University Hospital between 1997 and 2013 were enrolled. We investigated the association between the tumor size of EC assessed prior to surgery by MRI (anteroposterior [AP], transverse [TV], and craniocaudal [CC] diameters) and various clinical parameters including deep myometrial invasion and lymph node metastases. We subsequently examined the prognostic significance of tumor size in patients with EC. Survival analysis was performed using the Kaplan-Meier method, and prognostic factors were evaluated using the Cox’s proportional hazards regression model. Multivariate analysis identified increased AP diameter as an independent negative prognostic factor for overall survival (OS) (P = 0.037). A long AP diameter has prognostic value and the potential to be a predictive marker for surgical outcomes in patients with EC. Furthermore, AP diameter exhibited the greatest area under the curve (AUC) (0.727) for deep myometrial invasion, and CC diameter had the greatest AUC for lymph node metastases (0.854). Evaluation of tumor size parameters may aid in the identification of high-risk populations, which could improve treatment selection and patient outcomes. Impact Journals LLC 2018-05-01 /pmc/articles/PMC5955431/ /pubmed/29796179 http://dx.doi.org/10.18632/oncotarget.25248 Text en Copyright: © 2018 Nakamura et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Nakamura, Kohei Nakayama, Kentaro Ishikawa, Noriyoshi Minamoto, Toshiko Ishibashi, Tomoka Ohnishi, Kaori Yamashita, Hitomi Ono, Ruriko Sasamori, Hiroki Razia, Sultana Hossain, Mohammad Mahmud Kamrunnahar, Shanta Ishikawa, Masako Kyo, Satoru Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma |
title | Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma |
title_full | Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma |
title_fullStr | Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma |
title_full_unstemmed | Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma |
title_short | Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma |
title_sort | preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955431/ https://www.ncbi.nlm.nih.gov/pubmed/29796179 http://dx.doi.org/10.18632/oncotarget.25248 |
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