Construction of a tri-chromatic reporter cell line for the rapid and simple screening of splice-switching oligonucleotides targeting DMD exon 51 using high content screening

Splice-switching oligonucleotides (SSOs) that can modulate RNA splicing are used for the treatment of many genetic disorders. To enhance the efficacy of modulating splicing, it is important to optimize SSOs with regard to target sites, GC content, melting temperature (T(m) value), chemistries, and l...

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Detalles Bibliográficos
Autores principales: Shimo, Takenori, Tachibana, Keisuke, Obika, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955590/
https://www.ncbi.nlm.nih.gov/pubmed/29768479
http://dx.doi.org/10.1371/journal.pone.0197373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955590/
https://www.ncbi.nlm.nih.gov/pubmed/29768479
http://dx.doi.org/10.1371/journal.pone.0197373

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