Cargando…

Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism

Under nitrogen deprivation, the one-dimensional cyanobacterial organism Anabaena sp. PCC 7120 develops patterns of single, nitrogen-fixing cells separated by nearly regular intervals of photosynthetic vegetative cells. We study a minimal, stochastic model of developmental patterns in Anabaena that i...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Patti, Francesca, Lavacchi, Laura, Arbel-Goren, Rinat, Schein-Lubomirsky, Leora, Fanelli, Duccio, Stavans, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955598/
https://www.ncbi.nlm.nih.gov/pubmed/29727442
http://dx.doi.org/10.1371/journal.pbio.2004877
_version_ 1783323750829129728
author Di Patti, Francesca
Lavacchi, Laura
Arbel-Goren, Rinat
Schein-Lubomirsky, Leora
Fanelli, Duccio
Stavans, Joel
author_facet Di Patti, Francesca
Lavacchi, Laura
Arbel-Goren, Rinat
Schein-Lubomirsky, Leora
Fanelli, Duccio
Stavans, Joel
author_sort Di Patti, Francesca
collection PubMed
description Under nitrogen deprivation, the one-dimensional cyanobacterial organism Anabaena sp. PCC 7120 develops patterns of single, nitrogen-fixing cells separated by nearly regular intervals of photosynthetic vegetative cells. We study a minimal, stochastic model of developmental patterns in Anabaena that includes a nondiffusing activator, two diffusing inhibitor morphogens, demographic fluctuations in the number of morphogen molecules, and filament growth. By tracking developing filaments, we provide experimental evidence for different spatiotemporal roles of the two inhibitors during pattern maintenance and for small molecular copy numbers, justifying a stochastic approach. In the deterministic limit, the model yields Turing patterns within a region of parameter space that shrinks markedly as the inhibitor diffusivities become equal. Transient, noise-driven, stochastic Turing patterns are produced outside this region, which can then be fixed by downstream genetic commitment pathways, dramatically enhancing the robustness of pattern formation, also in the biologically relevant situation in which the inhibitors' diffusivities may be comparable.
format Online
Article
Text
id pubmed-5955598
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-59555982018-05-25 Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism Di Patti, Francesca Lavacchi, Laura Arbel-Goren, Rinat Schein-Lubomirsky, Leora Fanelli, Duccio Stavans, Joel PLoS Biol Research Article Under nitrogen deprivation, the one-dimensional cyanobacterial organism Anabaena sp. PCC 7120 develops patterns of single, nitrogen-fixing cells separated by nearly regular intervals of photosynthetic vegetative cells. We study a minimal, stochastic model of developmental patterns in Anabaena that includes a nondiffusing activator, two diffusing inhibitor morphogens, demographic fluctuations in the number of morphogen molecules, and filament growth. By tracking developing filaments, we provide experimental evidence for different spatiotemporal roles of the two inhibitors during pattern maintenance and for small molecular copy numbers, justifying a stochastic approach. In the deterministic limit, the model yields Turing patterns within a region of parameter space that shrinks markedly as the inhibitor diffusivities become equal. Transient, noise-driven, stochastic Turing patterns are produced outside this region, which can then be fixed by downstream genetic commitment pathways, dramatically enhancing the robustness of pattern formation, also in the biologically relevant situation in which the inhibitors' diffusivities may be comparable. Public Library of Science 2018-05-04 /pmc/articles/PMC5955598/ /pubmed/29727442 http://dx.doi.org/10.1371/journal.pbio.2004877 Text en © 2018 Di Patti et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Di Patti, Francesca
Lavacchi, Laura
Arbel-Goren, Rinat
Schein-Lubomirsky, Leora
Fanelli, Duccio
Stavans, Joel
Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism
title Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism
title_full Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism
title_fullStr Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism
title_full_unstemmed Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism
title_short Robust stochastic Turing patterns in the development of a one-dimensional cyanobacterial organism
title_sort robust stochastic turing patterns in the development of a one-dimensional cyanobacterial organism
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955598/
https://www.ncbi.nlm.nih.gov/pubmed/29727442
http://dx.doi.org/10.1371/journal.pbio.2004877
work_keys_str_mv AT dipattifrancesca robuststochasticturingpatternsinthedevelopmentofaonedimensionalcyanobacterialorganism
AT lavacchilaura robuststochasticturingpatternsinthedevelopmentofaonedimensionalcyanobacterialorganism
AT arbelgorenrinat robuststochasticturingpatternsinthedevelopmentofaonedimensionalcyanobacterialorganism
AT scheinlubomirskyleora robuststochasticturingpatternsinthedevelopmentofaonedimensionalcyanobacterialorganism
AT fanelliduccio robuststochasticturingpatternsinthedevelopmentofaonedimensionalcyanobacterialorganism
AT stavansjoel robuststochasticturingpatternsinthedevelopmentofaonedimensionalcyanobacterialorganism