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Importance of lysosomal cysteine proteases in lung disease

The human lysosomal cysteine proteases are a family of 11 proteases whose members include cathepsins B, C, H, L, and S. The biology of these proteases was largely ignored for decades because of their lysosomal location and the belief that their function was limited to the terminal degradation of pro...

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Detalles Bibliográficos
Autores principales: Wolters, Paul J, Chapman, Harold A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59556/
https://www.ncbi.nlm.nih.gov/pubmed/11667982
http://dx.doi.org/10.1186/rr29
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author Wolters, Paul J
Chapman, Harold A
author_facet Wolters, Paul J
Chapman, Harold A
author_sort Wolters, Paul J
collection PubMed
description The human lysosomal cysteine proteases are a family of 11 proteases whose members include cathepsins B, C, H, L, and S. The biology of these proteases was largely ignored for decades because of their lysosomal location and the belief that their function was limited to the terminal degradation of proteins. In the past 10 years, this view has changed as these proteases have been found to have specific functions within cells. This review highlights some of these functions, specifically their roles in matrix remodeling and in regulating the immune response, and their relationship to lung diseases.
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spelling pubmed-595562001-11-06 Importance of lysosomal cysteine proteases in lung disease Wolters, Paul J Chapman, Harold A Respir Res Review The human lysosomal cysteine proteases are a family of 11 proteases whose members include cathepsins B, C, H, L, and S. The biology of these proteases was largely ignored for decades because of their lysosomal location and the belief that their function was limited to the terminal degradation of proteins. In the past 10 years, this view has changed as these proteases have been found to have specific functions within cells. This review highlights some of these functions, specifically their roles in matrix remodeling and in regulating the immune response, and their relationship to lung diseases. BioMed Central 2000 2000-11-20 /pmc/articles/PMC59556/ /pubmed/11667982 http://dx.doi.org/10.1186/rr29 Text en Copyright © 2000 Current Science Ltd
spellingShingle Review
Wolters, Paul J
Chapman, Harold A
Importance of lysosomal cysteine proteases in lung disease
title Importance of lysosomal cysteine proteases in lung disease
title_full Importance of lysosomal cysteine proteases in lung disease
title_fullStr Importance of lysosomal cysteine proteases in lung disease
title_full_unstemmed Importance of lysosomal cysteine proteases in lung disease
title_short Importance of lysosomal cysteine proteases in lung disease
title_sort importance of lysosomal cysteine proteases in lung disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59556/
https://www.ncbi.nlm.nih.gov/pubmed/11667982
http://dx.doi.org/10.1186/rr29
work_keys_str_mv AT wolterspaulj importanceoflysosomalcysteineproteasesinlungdisease
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