The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication

Mammalian CST (CTC1-STN1-TEN1) complex fulfills numerous functions including rescue of the stalled replication forks and termination of telomerase action. In fission yeast lacking the CTC1 ortholog, the Stn1-Ten1 complex restricts telomerase action via its sumoylation-mediated interaction with Tpz1(...

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Detalles Bibliográficos
Autores principales: Matmati, Samah, Vaurs, Mélina, Escandell, José M., Maestroni, Laetitia, Nakamura, Toru M., Ferreira, Miguel G., Géli, Vincent, Coulon, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955624/
https://www.ncbi.nlm.nih.gov/pubmed/29774234
http://dx.doi.org/10.1126/sciadv.aar2740

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