Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy

Interleukin-15 (IL-15) can promote both innate and adaptive immune reactions by stimulating CD8(+)/CD4(+) T cells and natural killer cells (NK) while showing no effect in activating T-regulatory (Treg) cells or inducing activation-associated death among effector T cells and NK cells. Thus, IL-15 is...

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Detalles Bibliográficos
Autores principales: Hu, Qiyue, Ye, Xin, Qu, Xiangdong, Cui, Dongbing, Zhang, Lei, Xu, Zhibin, Wan, Hong, Zhang, Lianshan, Tao, Weikang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955975/
https://www.ncbi.nlm.nih.gov/pubmed/29769573
http://dx.doi.org/10.1038/s41598-018-25987-4

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