No significant differences in short-term renal prognosis between living kidney donors with and without diabetes

BACKGROUND: Renal prognosis in living kidney donors with diabetes is currently not known. In this study, we sought to investigate renal prognosis in living kidney donors with diabetes. METHODS: We retrospectively investigated 241 living kidney donors who underwent nephrectomy at Jichi Medical University Hospital between January 2000 and December 2015. Donors with a follow-up period of less than 1 year were excluded. The remaining donors were divided into a diabetic group and a non-diabetic group. Their clinical parameters before donation and renal prognosis after donation were compared. RESULTS: Of the 241 donors, 16 were excluded due to their follow-up period being less than 1 year. Of the remaining 225 donors, 14 were diabetic and 211 were non-diabetic. There were no significant differences in variables at pre-donation. The median follow-up period was 4.3 (1.5–10.7) and 4.6 (1.0–13.0) years in kidney donors with and without diabetes, respectively. At the end of follow-up, the estimated glomerular filtration rate was 51.7 ± 7.1 ml/min/1.73 m(2) in the diabetic group and 52.1 ± 12.2 ml/min/1.73 m(2) (p = 0.906) in the non-diabetic group; urine albumin excretion was 9.5 (2–251) mg/day (or mg/g creatinine) in the diabetic group and 6 (0–626) mg/day (or mg/g creatinine) in the non-diabetic group (p = 0.130); and urine protein excretion was 0.079 (0–0.41) g/day in the diabetic group and 0.051 (0–3.7) g/day in the non-diabetic group (p = 0.455). CONCLUSIONS: There were no significant differences in short-term renal prognosis between kidney donors with and without diabetes.