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Sample size re-estimation without un-blinding for time-to-event outcomes in oncology clinical trials
Sample size re-estimation is essential in oncology studies. However, the use of blinded sample size reassessment for survival data has been rarely reported. Based on the density function of the exponential distribution, an expectation-maximization (EM) algorithm of the hazard ratio was derived, and...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Editorial Department of Journal of Biomedical Research
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956254/ https://www.ncbi.nlm.nih.gov/pubmed/28630393 http://dx.doi.org/10.7555/JBR.31.20160111 |