The genetics of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting...

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Detalles Bibliográficos
Autores principales: Lomas, David A, Silverman, Edwin K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59565/
https://www.ncbi.nlm.nih.gov/pubmed/11686861
http://dx.doi.org/10.1186/rr34
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author Lomas, David A
Silverman, Edwin K
author_facet Lomas, David A
Silverman, Edwin K
author_sort Lomas, David A
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.
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spelling pubmed-595652001-11-06 The genetics of chronic obstructive pulmonary disease Lomas, David A Silverman, Edwin K Respir Res Review Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes. BioMed Central 2001 2001-01-11 /pmc/articles/PMC59565/ /pubmed/11686861 http://dx.doi.org/10.1186/rr34 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Review
Lomas, David A
Silverman, Edwin K
The genetics of chronic obstructive pulmonary disease
title The genetics of chronic obstructive pulmonary disease
title_full The genetics of chronic obstructive pulmonary disease
title_fullStr The genetics of chronic obstructive pulmonary disease
title_full_unstemmed The genetics of chronic obstructive pulmonary disease
title_short The genetics of chronic obstructive pulmonary disease
title_sort genetics of chronic obstructive pulmonary disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59565/
https://www.ncbi.nlm.nih.gov/pubmed/11686861
http://dx.doi.org/10.1186/rr34
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