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Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts

BACKGROUND: The current study was carried out to evaluate the effects of mycotoxin biodegradation agent (MBA, composed of Bacillus subtilis ANSB01G and Devosia sp. ANSB714) on relieving zearalenone (ZEA) and deoxynivalenol (DON) toxicosis in immature gilts. METHODS: A total of forty pre-pubertal fem...

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Autores principales: Shi, Donghui, Zhou, Jianchuan, Zhao, Lihong, Rong, Xiaoping, Fan, Yu, Hamid, Humera, Li, Wenqiang, Ji, Cheng, Ma, Qiugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956560/
https://www.ncbi.nlm.nih.gov/pubmed/29796255
http://dx.doi.org/10.1186/s40104-018-0255-z
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author Shi, Donghui
Zhou, Jianchuan
Zhao, Lihong
Rong, Xiaoping
Fan, Yu
Hamid, Humera
Li, Wenqiang
Ji, Cheng
Ma, Qiugang
author_facet Shi, Donghui
Zhou, Jianchuan
Zhao, Lihong
Rong, Xiaoping
Fan, Yu
Hamid, Humera
Li, Wenqiang
Ji, Cheng
Ma, Qiugang
author_sort Shi, Donghui
collection PubMed
description BACKGROUND: The current study was carried out to evaluate the effects of mycotoxin biodegradation agent (MBA, composed of Bacillus subtilis ANSB01G and Devosia sp. ANSB714) on relieving zearalenone (ZEA) and deoxynivalenol (DON) toxicosis in immature gilts. METHODS: A total of forty pre-pubertal female gilts (61.42 ± 1.18 kg) were randomly allocated to four diet treatments: CO (positive control); MO (negative control, ZEA 596.86 μg/kg feed and DON 796 μg/kg feed); COA (CO + 2 g MBA/kg feed); MOA (MO + 2 g MBA/kg feed). Each treatment contained 10 replicates with 1 gilt per replicate. Gilts were housed in an environmentally controlled room with the partially slatted floor. RESULTS: During the entire experimental period of 28 d, average daily gain (ADG) and average daily feed intake (ADFI) of gilts in MO group was significantly reduced compared with those in CO group. The vulva size of gilts was significantly higher in MO group than CO group. In addition, significant increases in the plasma levels of IgA, IgG, IL-8, IL-10 and PRL were determined in MO group compared with that in CO group. ZEA and DON in the diet up-regulated apoptotic caspase-3 in ovaries and uteri, along with down-regulated the anti-apoptotic protein Bcl-2 in ovaries. The supplementation of MBA into diets co-contaminated with ZEA and DON significantly increased ADG, decreased the vulva sizes, reduced the levels of IgG, IL-8 and PRL in plasma, and regulated apoptosis in ovaries and uteri of gilts. CONCLUSIONS: The present results indicated that feeding diet contaminated with ZEA and DON simultaneously (596.86 μg/kg + 796 μg/kg) had detrimental effects on growth performance, plasma immune function and reproductive status of gilts. And MBA could reduce the negative impacts of these two toxins, believed as a promising feed additive for mitigating toxicosis of ZEA and DON at low levels in gilts.
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spelling pubmed-59565602018-05-24 Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts Shi, Donghui Zhou, Jianchuan Zhao, Lihong Rong, Xiaoping Fan, Yu Hamid, Humera Li, Wenqiang Ji, Cheng Ma, Qiugang J Anim Sci Biotechnol Research BACKGROUND: The current study was carried out to evaluate the effects of mycotoxin biodegradation agent (MBA, composed of Bacillus subtilis ANSB01G and Devosia sp. ANSB714) on relieving zearalenone (ZEA) and deoxynivalenol (DON) toxicosis in immature gilts. METHODS: A total of forty pre-pubertal female gilts (61.42 ± 1.18 kg) were randomly allocated to four diet treatments: CO (positive control); MO (negative control, ZEA 596.86 μg/kg feed and DON 796 μg/kg feed); COA (CO + 2 g MBA/kg feed); MOA (MO + 2 g MBA/kg feed). Each treatment contained 10 replicates with 1 gilt per replicate. Gilts were housed in an environmentally controlled room with the partially slatted floor. RESULTS: During the entire experimental period of 28 d, average daily gain (ADG) and average daily feed intake (ADFI) of gilts in MO group was significantly reduced compared with those in CO group. The vulva size of gilts was significantly higher in MO group than CO group. In addition, significant increases in the plasma levels of IgA, IgG, IL-8, IL-10 and PRL were determined in MO group compared with that in CO group. ZEA and DON in the diet up-regulated apoptotic caspase-3 in ovaries and uteri, along with down-regulated the anti-apoptotic protein Bcl-2 in ovaries. The supplementation of MBA into diets co-contaminated with ZEA and DON significantly increased ADG, decreased the vulva sizes, reduced the levels of IgG, IL-8 and PRL in plasma, and regulated apoptosis in ovaries and uteri of gilts. CONCLUSIONS: The present results indicated that feeding diet contaminated with ZEA and DON simultaneously (596.86 μg/kg + 796 μg/kg) had detrimental effects on growth performance, plasma immune function and reproductive status of gilts. And MBA could reduce the negative impacts of these two toxins, believed as a promising feed additive for mitigating toxicosis of ZEA and DON at low levels in gilts. BioMed Central 2018-05-16 /pmc/articles/PMC5956560/ /pubmed/29796255 http://dx.doi.org/10.1186/s40104-018-0255-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Shi, Donghui
Zhou, Jianchuan
Zhao, Lihong
Rong, Xiaoping
Fan, Yu
Hamid, Humera
Li, Wenqiang
Ji, Cheng
Ma, Qiugang
Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts
title Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts
title_full Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts
title_fullStr Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts
title_full_unstemmed Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts
title_short Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts
title_sort alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956560/
https://www.ncbi.nlm.nih.gov/pubmed/29796255
http://dx.doi.org/10.1186/s40104-018-0255-z
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