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Orbital implant exposure after Acanthamoeba panophthalmitis

PURPOSE: Acanthamoeba is a protozoa that can lead to severe ocular disease and sequelae. Although intraocular Acanthamoeba infection is rare, the following case demonstrates an unusual presentation of recurrent Acanthamoeba infection in a 30 year old contact lens wearing male. OBSERVATIONS: After pr...

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Autores principales: Baker, Meredith S., Maltry, Amanda C., Syed, Nasreen A., Allen, Richard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956657/
https://www.ncbi.nlm.nih.gov/pubmed/29780912
http://dx.doi.org/10.1016/j.ajoc.2018.01.043
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author Baker, Meredith S.
Maltry, Amanda C.
Syed, Nasreen A.
Allen, Richard C.
author_facet Baker, Meredith S.
Maltry, Amanda C.
Syed, Nasreen A.
Allen, Richard C.
author_sort Baker, Meredith S.
collection PubMed
description PURPOSE: Acanthamoeba is a protozoa that can lead to severe ocular disease and sequelae. Although intraocular Acanthamoeba infection is rare, the following case demonstrates an unusual presentation of recurrent Acanthamoeba infection in a 30 year old contact lens wearing male. OBSERVATIONS: After presenting with recurrent Acanthamoeba keratitis and undergoing various treatments, the patient developed nodular scleritis, which evolved into panophthalmitis, and ultimately, required enucleation. Eight months post-operatively, the patient developed orbital implant exposure secondary to persistent Acanthamoeba infection and underwent removal of the implant and aggressive, systemic treatment involving a multispecialty care team. He then underwent placement of a dermis fat graft and had no signs of persistent infection at the time of last follow-up, which was 24 months after placement of the dermis fat graft. CONCLUSIONS: and Importance: To the authors' knowledge, this is the first known case of Acanthamoeba infection causing orbital implant exposure. Persistent infection should be considered in Acanthamoeba patients who have undergone enucleation and have orbital implant exposure. Better knowledge regarding the pathogenesis and extracorneal complications of this challenging disease may improve patient care and outcomes.
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spelling pubmed-59566572018-05-18 Orbital implant exposure after Acanthamoeba panophthalmitis Baker, Meredith S. Maltry, Amanda C. Syed, Nasreen A. Allen, Richard C. Am J Ophthalmol Case Rep Brief report PURPOSE: Acanthamoeba is a protozoa that can lead to severe ocular disease and sequelae. Although intraocular Acanthamoeba infection is rare, the following case demonstrates an unusual presentation of recurrent Acanthamoeba infection in a 30 year old contact lens wearing male. OBSERVATIONS: After presenting with recurrent Acanthamoeba keratitis and undergoing various treatments, the patient developed nodular scleritis, which evolved into panophthalmitis, and ultimately, required enucleation. Eight months post-operatively, the patient developed orbital implant exposure secondary to persistent Acanthamoeba infection and underwent removal of the implant and aggressive, systemic treatment involving a multispecialty care team. He then underwent placement of a dermis fat graft and had no signs of persistent infection at the time of last follow-up, which was 24 months after placement of the dermis fat graft. CONCLUSIONS: and Importance: To the authors' knowledge, this is the first known case of Acanthamoeba infection causing orbital implant exposure. Persistent infection should be considered in Acanthamoeba patients who have undergone enucleation and have orbital implant exposure. Better knowledge regarding the pathogenesis and extracorneal complications of this challenging disease may improve patient care and outcomes. Elsevier 2018-01-31 /pmc/articles/PMC5956657/ /pubmed/29780912 http://dx.doi.org/10.1016/j.ajoc.2018.01.043 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief report
Baker, Meredith S.
Maltry, Amanda C.
Syed, Nasreen A.
Allen, Richard C.
Orbital implant exposure after Acanthamoeba panophthalmitis
title Orbital implant exposure after Acanthamoeba panophthalmitis
title_full Orbital implant exposure after Acanthamoeba panophthalmitis
title_fullStr Orbital implant exposure after Acanthamoeba panophthalmitis
title_full_unstemmed Orbital implant exposure after Acanthamoeba panophthalmitis
title_short Orbital implant exposure after Acanthamoeba panophthalmitis
title_sort orbital implant exposure after acanthamoeba panophthalmitis
topic Brief report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956657/
https://www.ncbi.nlm.nih.gov/pubmed/29780912
http://dx.doi.org/10.1016/j.ajoc.2018.01.043
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