The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults

INTRODUCTION: Alzheimer's disease (AD) patients exhibit temporally graded memory loss with remote memories remaining more intact than recent memories. It is unclear whether this temporal pattern is observable in clinically normal adults with amyloid pathology (i.e. preclinical AD). METHODS: Par...

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Autores principales: Orlovsky, Irina, Huijbers, Willem, Hanseeuw, Bernard J., Mormino, Elizabeth C., Hedden, Trey, Buckley, Rachel F., LaPoint, Molly, Rabin, Jennifer S., Rentz, Dorene M., Johnson, Keith A., Sperling, Reisa A., Papp, Kathryn V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956796/
https://www.ncbi.nlm.nih.gov/pubmed/29780861
http://dx.doi.org/10.1016/j.dadm.2017.11.003
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author Orlovsky, Irina
Huijbers, Willem
Hanseeuw, Bernard J.
Mormino, Elizabeth C.
Hedden, Trey
Buckley, Rachel F.
LaPoint, Molly
Rabin, Jennifer S.
Rentz, Dorene M.
Johnson, Keith A.
Sperling, Reisa A.
Papp, Kathryn V.
author_facet Orlovsky, Irina
Huijbers, Willem
Hanseeuw, Bernard J.
Mormino, Elizabeth C.
Hedden, Trey
Buckley, Rachel F.
LaPoint, Molly
Rabin, Jennifer S.
Rentz, Dorene M.
Johnson, Keith A.
Sperling, Reisa A.
Papp, Kathryn V.
author_sort Orlovsky, Irina
collection PubMed
description INTRODUCTION: Alzheimer's disease (AD) patients exhibit temporally graded memory loss with remote memories remaining more intact than recent memories. It is unclear whether this temporal pattern is observable in clinically normal adults with amyloid pathology (i.e. preclinical AD). METHODS: Participants were asked to recall the names of famous figures most prominent recently (famous after 1990) and remotely (famous from 1960–1980) and were provided with a phonemic cue to ensure that memory failure was not purely due to verbal retrieval weaknesses. In addition, participants identified line drawings of objects. Clinically normal older adults (n = 125) were identified as amyloid β positive or negative (Aβ+/−) using Pittsburgh compound B positron emission tomography. The relationship between Aβ+/− and recall of remote and recent famous face-names and objects was examined using repeated measures analyses and general linear models controlling for demographics and media usage. RESULTS: When provided with a phonemic cue, Aβ+ participants recalled the names of fewer recent famous faces compared with Aβ− participants. However, recall of remote famous face-names and objects did not differ by Aβ group. DISCUSSION: Relative sparing of remotely learned information compared with recently learned information is (1) detectable in the preclinical stages of AD and (2) related to amyloid pathology. Both this temporal gradient and assessment of person-centered rather than object-centered semantic information may be particularly meaningful for tracking early memory changes in the AD trajectory.
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spelling pubmed-59567962018-05-18 The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults Orlovsky, Irina Huijbers, Willem Hanseeuw, Bernard J. Mormino, Elizabeth C. Hedden, Trey Buckley, Rachel F. LaPoint, Molly Rabin, Jennifer S. Rentz, Dorene M. Johnson, Keith A. Sperling, Reisa A. Papp, Kathryn V. Alzheimers Dement (Amst) Cognitive & Behavioral Assessment INTRODUCTION: Alzheimer's disease (AD) patients exhibit temporally graded memory loss with remote memories remaining more intact than recent memories. It is unclear whether this temporal pattern is observable in clinically normal adults with amyloid pathology (i.e. preclinical AD). METHODS: Participants were asked to recall the names of famous figures most prominent recently (famous after 1990) and remotely (famous from 1960–1980) and were provided with a phonemic cue to ensure that memory failure was not purely due to verbal retrieval weaknesses. In addition, participants identified line drawings of objects. Clinically normal older adults (n = 125) were identified as amyloid β positive or negative (Aβ+/−) using Pittsburgh compound B positron emission tomography. The relationship between Aβ+/− and recall of remote and recent famous face-names and objects was examined using repeated measures analyses and general linear models controlling for demographics and media usage. RESULTS: When provided with a phonemic cue, Aβ+ participants recalled the names of fewer recent famous faces compared with Aβ− participants. However, recall of remote famous face-names and objects did not differ by Aβ group. DISCUSSION: Relative sparing of remotely learned information compared with recently learned information is (1) detectable in the preclinical stages of AD and (2) related to amyloid pathology. Both this temporal gradient and assessment of person-centered rather than object-centered semantic information may be particularly meaningful for tracking early memory changes in the AD trajectory. Elsevier 2017-11-23 /pmc/articles/PMC5956796/ /pubmed/29780861 http://dx.doi.org/10.1016/j.dadm.2017.11.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Cognitive & Behavioral Assessment
Orlovsky, Irina
Huijbers, Willem
Hanseeuw, Bernard J.
Mormino, Elizabeth C.
Hedden, Trey
Buckley, Rachel F.
LaPoint, Molly
Rabin, Jennifer S.
Rentz, Dorene M.
Johnson, Keith A.
Sperling, Reisa A.
Papp, Kathryn V.
The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults
title The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults
title_full The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults
title_fullStr The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults
title_full_unstemmed The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults
title_short The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults
title_sort relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults
topic Cognitive & Behavioral Assessment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956796/
https://www.ncbi.nlm.nih.gov/pubmed/29780861
http://dx.doi.org/10.1016/j.dadm.2017.11.003
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