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Similar pattern of atrophy in early- and late-onset Alzheimer's disease
INTRODUCTION: Previous research on structural changes in early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) have reported inconsistent findings. METHODS: In the present substudy of the Gothenburg MCI study, 1.5 T scans were used to estimate lobar and hippocamp...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956802/ https://www.ncbi.nlm.nih.gov/pubmed/29780870 http://dx.doi.org/10.1016/j.dadm.2018.02.001 |
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author | Eckerström, Carl Klasson, Niklas Olsson, Erik Selnes, Per Rolstad, Sindre Wallin, Anders |
author_facet | Eckerström, Carl Klasson, Niklas Olsson, Erik Selnes, Per Rolstad, Sindre Wallin, Anders |
author_sort | Eckerström, Carl |
collection | PubMed |
description | INTRODUCTION: Previous research on structural changes in early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) have reported inconsistent findings. METHODS: In the present substudy of the Gothenburg MCI study, 1.5 T scans were used to estimate lobar and hippocampal volumes using FreeSurfer. Study participants (N = 145) included 63 patients with AD, (24 patients with EOAD [aged ≤65 years], 39 patients with LOAD [aged >65 years]), 25 healthy controls aged ≤65 years, and 57 healthy controls aged >65 years. RESULTS: Hippocampal atrophy is the most prominent feature of both EOAD and LOAD compared with controls. Direct comparison between EOAD and LOAD showed that the differences between the groups did not remain after correcting for age. DISCUSSION: Structurally, EOAD and LOAD does not seem to be different nosological entities. The difference in brain volumes between the groups compared with controls is likely due to age-related atrophy. |
format | Online Article Text |
id | pubmed-5956802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-59568022018-05-18 Similar pattern of atrophy in early- and late-onset Alzheimer's disease Eckerström, Carl Klasson, Niklas Olsson, Erik Selnes, Per Rolstad, Sindre Wallin, Anders Alzheimers Dement (Amst) Special Section: State of the Field: Advances in Neuroimaging from the 2017 Alzheimer’s Imaging Consortium. (Guest Editors: Drs. David Wolk, Victor Villemagne & Bradford Dickerson) INTRODUCTION: Previous research on structural changes in early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) have reported inconsistent findings. METHODS: In the present substudy of the Gothenburg MCI study, 1.5 T scans were used to estimate lobar and hippocampal volumes using FreeSurfer. Study participants (N = 145) included 63 patients with AD, (24 patients with EOAD [aged ≤65 years], 39 patients with LOAD [aged >65 years]), 25 healthy controls aged ≤65 years, and 57 healthy controls aged >65 years. RESULTS: Hippocampal atrophy is the most prominent feature of both EOAD and LOAD compared with controls. Direct comparison between EOAD and LOAD showed that the differences between the groups did not remain after correcting for age. DISCUSSION: Structurally, EOAD and LOAD does not seem to be different nosological entities. The difference in brain volumes between the groups compared with controls is likely due to age-related atrophy. Elsevier 2018-03-01 /pmc/articles/PMC5956802/ /pubmed/29780870 http://dx.doi.org/10.1016/j.dadm.2018.02.001 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Special Section: State of the Field: Advances in Neuroimaging from the 2017 Alzheimer’s Imaging Consortium. (Guest Editors: Drs. David Wolk, Victor Villemagne & Bradford Dickerson) Eckerström, Carl Klasson, Niklas Olsson, Erik Selnes, Per Rolstad, Sindre Wallin, Anders Similar pattern of atrophy in early- and late-onset Alzheimer's disease |
title | Similar pattern of atrophy in early- and late-onset Alzheimer's disease |
title_full | Similar pattern of atrophy in early- and late-onset Alzheimer's disease |
title_fullStr | Similar pattern of atrophy in early- and late-onset Alzheimer's disease |
title_full_unstemmed | Similar pattern of atrophy in early- and late-onset Alzheimer's disease |
title_short | Similar pattern of atrophy in early- and late-onset Alzheimer's disease |
title_sort | similar pattern of atrophy in early- and late-onset alzheimer's disease |
topic | Special Section: State of the Field: Advances in Neuroimaging from the 2017 Alzheimer’s Imaging Consortium. (Guest Editors: Drs. David Wolk, Victor Villemagne & Bradford Dickerson) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956802/ https://www.ncbi.nlm.nih.gov/pubmed/29780870 http://dx.doi.org/10.1016/j.dadm.2018.02.001 |
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