Cargando…

γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport

BACKGROUND: Ceramide synthesis and metabolism is a promising target in cancer drug development. γ-tocotrienol (GT3), a member of the vitamin E family, orchestrates multiple effects that ensure the induction of apoptosis in both, wild-type and RAS-mutated pancreatic cancer cells. Here, we investigate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palau, Victoria E., Chakraborty, Kanishka, Wann, Daniel, Lightner, Janet, Hilton, Keely, Brannon, Marianne, Stone, William, Krishnan, Koyamangalath
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956825/ https://www.ncbi.nlm.nih.gov/pubmed/29769046 http://dx.doi.org/10.1186/s12885-018-4462-y

Ejemplares similares

Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells
por: Moore, Christine, et al.
Publicado: (2020)

Gamma (γ) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (γ) expression in SW 480 human colon cancer cell lines
por: Campbell, Sharon E, et al.
Publicado: (2003)

Apoptotic Sphingolipid Ceramide in Cancer Therapy
por: Huang, Wei-Ching, et al.
Publicado: (2011)

Sphingolipids and ceramides in human aqueous humor
por: Aljohani, Ayman J., et al.
Publicado: (2013)

In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells
por: McGoldrick, Christopher A, et al.
Publicado: (2014)

Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets
por: Young, Simon A., et al.
Publicado: (2012)

On ceramides, other sphingolipids and impaired glucose homeostasis()
por: Larsen, Philip J., et al.
Publicado: (2014)

The Role of Sphingolipids and Ceramide in Pulmonary Inflammation in Cystic Fibrosis
por: Becker, Katrin Anne, et al.
Publicado: (2010)

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides
por: Kol, Matthijs, et al.
Publicado: (2019)

Circulating Ceramides- Are Origins Important for Sphingolipid Biomarkers and Treatments?
por: Mah, Michael, et al.
Publicado: (2021)

Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer
por: McGoldrick, Christopher A, et al.
Publicado: (2014)

Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction
por: Boslem, Ebru, et al.
Publicado: (2012)

Sphingolipids and Atherosclerosis: The Dual Role of Ceramide and Sphingosine-1-Phosphate
por: Piccoli, Marco, et al.
Publicado: (2023)

On-Tissue Localization of Ceramides and Other Sphingolipids by MALDI Mass Spectrometry Imaging
por: Jones, E. Ellen, et al.
Publicado: (2014)

Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
por: Bandet, Cécile L., et al.
Publicado: (2019)

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles
por: Crivelli, Simone M., et al.
Publicado: (2022)

Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis
por: Xie, Tian, et al.
Publicado: (2023)

Differential Effects of Pravastatin and Simvastatin on the Growth of Tumor Cells from Different Organ Sites
por: Menter, David G., et al.
Publicado: (2011)

Hypertension Is Associated with Marked Alterations in Sphingolipid Biology: A Potential Role for Ceramide
por: Spijkers, Léon J. A., et al.
Publicado: (2011)

Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover
por: Simon, Jorge, et al.
Publicado: (2019)

Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress
por: Varzideh, Fahimeh, et al.
Publicado: (2022)

Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and Opportunities
por: Lai, Michele, et al.
Publicado: (2019)

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
por: Johnson, Elizabeth L., et al.
Publicado: (2020)

Chasing the Major Sphingolipids on Earth: Automated Annotation of Plant Glycosyl Inositol Phospho Ceramides by Glycolipidomics
por: Panzenboeck, Lisa, et al.
Publicado: (2020)

Sphingolipid Profiling Reveals Different Extent of Ceramide Accumulation in Bovine Retroperitoneal and Subcutaneous Adipose Tissues
por: Leung, Yue Hei, et al.
Publicado: (2020)

The sphingolipids ceramide and inositol phosphorylceramide protect the Leishmania major membrane from sterol-specific toxins
por: Haram, Chaitanya S., et al.
Publicado: (2023)

Yeast Svf1 binds ceramides and contributes to sphingolipid metabolism at the ER cis-Golgi interface
por: Limar, Sergej, et al.
Publicado: (2023)

Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection
por: Lekli, Istvan, et al.
Publicado: (2010)

Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection
por: Ledet, Grace A., et al.
Publicado: (2016)

Nicotine-induced cessation of embryonic development is reversed by γ-tocotrienol in mice
por: Kamsani, Yuhaniza Shafinie, et al.
Publicado: (2013)

γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway
por: Xie, Ling, et al.
Publicado: (2023)

Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells
por: Pang, Kok-Lun, et al.
Publicado: (2022)

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer
por: Lee, Wing-Kee, et al.
Publicado: (2021)

Insights into abnormal sphingolipid metabolism in multiple sclerosis: targeting ceramide biosynthesis as a unique therapeutic strategy
por: Dasgupta, Somsankar, et al.
Publicado: (2017)

Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog
por: Deng, Yaqin, et al.
Publicado: (2021)

Ceramide-1-phosphate transfer protein promotes sphingolipid reorientation needed for binding during membrane interaction
por: Gao, Yong-Guang, et al.
Publicado: (2021)

γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status
por: Singh, Vijay K., et al.
Publicado: (2016)

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids
por: Muir, Alexander, et al.
Publicado: (2014)

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis
por: Igarashi, Tami, et al.
Publicado: (2023)

The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro
por: Ibrahim, Nor Faeizah, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gli96opf6h2bvetq03sr4sg0g5