Cargando…

Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma

Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9,...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Yuhong, McLane, Michael, Levitt, Roy C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59572/
https://www.ncbi.nlm.nih.gov/pubmed/11686869
http://dx.doi.org/10.1186/rr42
Descripción
Sumario:Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the T(H)2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other T(H)2 cytokines such as IL-4, IL-5 and IL-13.