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Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma

Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9,...

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Detalles Bibliográficos
Autores principales: Zhou, Yuhong, McLane, Michael, Levitt, Roy C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59572/
https://www.ncbi.nlm.nih.gov/pubmed/11686869
http://dx.doi.org/10.1186/rr42
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author Zhou, Yuhong
McLane, Michael
Levitt, Roy C
author_facet Zhou, Yuhong
McLane, Michael
Levitt, Roy C
author_sort Zhou, Yuhong
collection PubMed
description Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the T(H)2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other T(H)2 cytokines such as IL-4, IL-5 and IL-13.
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spelling pubmed-595722001-11-06 Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma Zhou, Yuhong McLane, Michael Levitt, Roy C Respir Res Review Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the T(H)2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other T(H)2 cytokines such as IL-4, IL-5 and IL-13. BioMed Central 2001 2001-02-15 /pmc/articles/PMC59572/ /pubmed/11686869 http://dx.doi.org/10.1186/rr42 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Review
Zhou, Yuhong
McLane, Michael
Levitt, Roy C
Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
title Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
title_full Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
title_fullStr Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
title_full_unstemmed Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
title_short Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
title_sort th2 cytokines and asthma — interleukin-9 as a therapeutic target for asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59572/
https://www.ncbi.nlm.nih.gov/pubmed/11686869
http://dx.doi.org/10.1186/rr42
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