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Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9,...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2001
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59572/ https://www.ncbi.nlm.nih.gov/pubmed/11686869 http://dx.doi.org/10.1186/rr42 |
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author | Zhou, Yuhong McLane, Michael Levitt, Roy C |
author_facet | Zhou, Yuhong McLane, Michael Levitt, Roy C |
author_sort | Zhou, Yuhong |
collection | PubMed |
description | Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the T(H)2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other T(H)2 cytokines such as IL-4, IL-5 and IL-13. |
format | Text |
id | pubmed-59572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-595722001-11-06 Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma Zhou, Yuhong McLane, Michael Levitt, Roy C Respir Res Review Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (T(H)2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the T(H)2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other T(H)2 cytokines such as IL-4, IL-5 and IL-13. BioMed Central 2001 2001-02-15 /pmc/articles/PMC59572/ /pubmed/11686869 http://dx.doi.org/10.1186/rr42 Text en Copyright © 2001 BioMed Central Ltd |
spellingShingle | Review Zhou, Yuhong McLane, Michael Levitt, Roy C Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma |
title | Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma |
title_full | Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma |
title_fullStr | Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma |
title_full_unstemmed | Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma |
title_short | Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma |
title_sort | th2 cytokines and asthma — interleukin-9 as a therapeutic target for asthma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59572/ https://www.ncbi.nlm.nih.gov/pubmed/11686869 http://dx.doi.org/10.1186/rr42 |
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