Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era

Surgery and radiotherapy are mainstays of treatment for ependymomas (EPNs). Recent molecular subgrouping could be superior to histopathological grading for predicting the prognosis of patients with EPNs. Gross total resection is an effective treatment approach regardless of its locations or patholog...

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Detalles Bibliográficos
Autores principales: Jung, Tae-Young, Jung, Shin, Kook, Hoon, Baek, Hee-Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurosurgical Society 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957310/
https://www.ncbi.nlm.nih.gov/pubmed/29742878
http://dx.doi.org/10.3340/jkns.2018.0003
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author Jung, Tae-Young
Jung, Shin
Kook, Hoon
Baek, Hee-Jo
author_facet Jung, Tae-Young
Jung, Shin
Kook, Hoon
Baek, Hee-Jo
author_sort Jung, Tae-Young
collection PubMed
description Surgery and radiotherapy are mainstays of treatment for ependymomas (EPNs). Recent molecular subgrouping could be superior to histopathological grading for predicting the prognosis of patients with EPNs. Gross total resection is an effective treatment approach regardless of its locations or pathologic grades. Adjuvant therapeutic strategies could be decided based on molecular subgrouping with risk-stratification. Information of histologic-molecular biology is now providing clues to therapeutic insights.
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spelling pubmed-59573102018-05-18 Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era Jung, Tae-Young Jung, Shin Kook, Hoon Baek, Hee-Jo J Korean Neurosurg Soc Review Article Surgery and radiotherapy are mainstays of treatment for ependymomas (EPNs). Recent molecular subgrouping could be superior to histopathological grading for predicting the prognosis of patients with EPNs. Gross total resection is an effective treatment approach regardless of its locations or pathologic grades. Adjuvant therapeutic strategies could be decided based on molecular subgrouping with risk-stratification. Information of histologic-molecular biology is now providing clues to therapeutic insights. Korean Neurosurgical Society 2018-05 2018-05-01 /pmc/articles/PMC5957310/ /pubmed/29742878 http://dx.doi.org/10.3340/jkns.2018.0003 Text en Copyright © 2018 Korean Neurosurgical Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jung, Tae-Young
Jung, Shin
Kook, Hoon
Baek, Hee-Jo
Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era
title Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era
title_full Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era
title_fullStr Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era
title_full_unstemmed Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era
title_short Treatment Decisions of World Health Organization Grade II and III Ependymomas in Molecular Era
title_sort treatment decisions of world health organization grade ii and iii ependymomas in molecular era
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957310/
https://www.ncbi.nlm.nih.gov/pubmed/29742878
http://dx.doi.org/10.3340/jkns.2018.0003
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