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Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine
Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine. Activated γδ T cells express adenosine receptors at high levels, which enables them to deprive Foxp3(+) T cells of adenosine, and to...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957379/ https://www.ncbi.nlm.nih.gov/pubmed/29771938 http://dx.doi.org/10.1371/journal.pone.0197189 |
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author | Liang, Dongchun Woo, Jeong-Im Shao, Hui Born, Willi K. O'Brien, Rebecca L. Kaplan, Henry J. Sun, Deming |
author_facet | Liang, Dongchun Woo, Jeong-Im Shao, Hui Born, Willi K. O'Brien, Rebecca L. Kaplan, Henry J. Sun, Deming |
author_sort | Liang, Dongchun |
collection | PubMed |
description | Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine. Activated γδ T cells express adenosine receptors at high levels, which enables them to deprive Foxp3(+) T cells of adenosine, and to inhibit their expansion. Meanwhile, cell-free supernatants of γδ T cell cultures enhance Foxp3 T cell expansion. Thus, inhibition and enhancement by γδ T cells of Foxp3 T cell response are a reflection of the balance between adenosine production and absorption by γδ T cells. Non-activated γδ T cells produce adenosine but bind little, and thus enhance the Foxp3 T cell response. Activated γδ T cells express high density of adenosine receptors and have a greatly increased ability to bind adenosine. Extracellular adenosine metabolism and expression of adenosine receptor A2ARs by γδ T cells played a major role in the outcome of γδ and Foxp3 T cell interactions. A better understanding of the functional conversion of γδ T cells could lead to γδ T cell-targeted immunotherapies for related diseases. |
format | Online Article Text |
id | pubmed-5957379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59573792018-05-31 Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine Liang, Dongchun Woo, Jeong-Im Shao, Hui Born, Willi K. O'Brien, Rebecca L. Kaplan, Henry J. Sun, Deming PLoS One Research Article Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine. Activated γδ T cells express adenosine receptors at high levels, which enables them to deprive Foxp3(+) T cells of adenosine, and to inhibit their expansion. Meanwhile, cell-free supernatants of γδ T cell cultures enhance Foxp3 T cell expansion. Thus, inhibition and enhancement by γδ T cells of Foxp3 T cell response are a reflection of the balance between adenosine production and absorption by γδ T cells. Non-activated γδ T cells produce adenosine but bind little, and thus enhance the Foxp3 T cell response. Activated γδ T cells express high density of adenosine receptors and have a greatly increased ability to bind adenosine. Extracellular adenosine metabolism and expression of adenosine receptor A2ARs by γδ T cells played a major role in the outcome of γδ and Foxp3 T cell interactions. A better understanding of the functional conversion of γδ T cells could lead to γδ T cell-targeted immunotherapies for related diseases. Public Library of Science 2018-05-17 /pmc/articles/PMC5957379/ /pubmed/29771938 http://dx.doi.org/10.1371/journal.pone.0197189 Text en © 2018 Liang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Liang, Dongchun Woo, Jeong-Im Shao, Hui Born, Willi K. O'Brien, Rebecca L. Kaplan, Henry J. Sun, Deming Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine |
title | Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine |
title_full | Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine |
title_fullStr | Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine |
title_full_unstemmed | Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine |
title_short | Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine |
title_sort | ability of γδ t cells to modulate the foxp3 t cell response is dependent on adenosine |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957379/ https://www.ncbi.nlm.nih.gov/pubmed/29771938 http://dx.doi.org/10.1371/journal.pone.0197189 |
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