Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome

During RNA virus infection, the adaptor protein MAVS recruits TRAF3 and TRAF6 to form a signalosome, which is critical to induce the production of type I interferons (IFNs) and proinflammatory cytokines. While activation of the MAVS/TRAF3/TRAF6 signalosome is well studied, the negative regulation of...

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Detalles Bibliográficos
Autores principales: Zhang, Liting, Liu, Jin, Qian, Liping, Feng, Qian, Wang, Xiaofang, Yuan, Yukang, Zuo, Yibo, Cheng, Qiao, Miao, Ying, Guo, Tingting, Zheng, Xiaofeng, Zheng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957451/
https://www.ncbi.nlm.nih.gov/pubmed/29734366
http://dx.doi.org/10.1371/journal.ppat.1007067

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