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LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
Glucose homeostasis depends critically on insulin that is secreted by pancreatic β-cells. Serum glucose, which is directly sensed by β-cells, stimulates depolarization- and Ca(2+)-dependent exocytosis of insulin granules. Here we show that pancreatic islets prominently express LRRC8A and LRRC8D, sub...
Autores principales: | Stuhlmann, Till, Planells-Cases, Rosa, Jentsch, Thomas J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958052/ https://www.ncbi.nlm.nih.gov/pubmed/29773801 http://dx.doi.org/10.1038/s41467-018-04353-y |
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