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MxB is an interferon-induced restriction factor of human herpesviruses

The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus r...

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Autores principales: Crameri, Michel, Bauer, Michael, Caduff, Nicole, Walker, Raphael, Steiner, Fiona, Franzoso, Francesca D., Gujer, Cornelia, Boucke, Karin, Kucera, Talissa, Zbinden, Andrea, Münz, Christian, Fraefel, Cornel, Greber, Urs F., Pavlovic, Jovan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958057/
https://www.ncbi.nlm.nih.gov/pubmed/29773792
http://dx.doi.org/10.1038/s41467-018-04379-2
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author Crameri, Michel
Bauer, Michael
Caduff, Nicole
Walker, Raphael
Steiner, Fiona
Franzoso, Francesca D.
Gujer, Cornelia
Boucke, Karin
Kucera, Talissa
Zbinden, Andrea
Münz, Christian
Fraefel, Cornel
Greber, Urs F.
Pavlovic, Jovan
author_facet Crameri, Michel
Bauer, Michael
Caduff, Nicole
Walker, Raphael
Steiner, Fiona
Franzoso, Francesca D.
Gujer, Cornelia
Boucke, Karin
Kucera, Talissa
Zbinden, Andrea
Münz, Christian
Fraefel, Cornel
Greber, Urs F.
Pavlovic, Jovan
author_sort Crameri, Michel
collection PubMed
description The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi’s sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid.
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spelling pubmed-59580572018-05-21 MxB is an interferon-induced restriction factor of human herpesviruses Crameri, Michel Bauer, Michael Caduff, Nicole Walker, Raphael Steiner, Fiona Franzoso, Francesca D. Gujer, Cornelia Boucke, Karin Kucera, Talissa Zbinden, Andrea Münz, Christian Fraefel, Cornel Greber, Urs F. Pavlovic, Jovan Nat Commun Article The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi’s sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid. Nature Publishing Group UK 2018-05-17 /pmc/articles/PMC5958057/ /pubmed/29773792 http://dx.doi.org/10.1038/s41467-018-04379-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Crameri, Michel
Bauer, Michael
Caduff, Nicole
Walker, Raphael
Steiner, Fiona
Franzoso, Francesca D.
Gujer, Cornelia
Boucke, Karin
Kucera, Talissa
Zbinden, Andrea
Münz, Christian
Fraefel, Cornel
Greber, Urs F.
Pavlovic, Jovan
MxB is an interferon-induced restriction factor of human herpesviruses
title MxB is an interferon-induced restriction factor of human herpesviruses
title_full MxB is an interferon-induced restriction factor of human herpesviruses
title_fullStr MxB is an interferon-induced restriction factor of human herpesviruses
title_full_unstemmed MxB is an interferon-induced restriction factor of human herpesviruses
title_short MxB is an interferon-induced restriction factor of human herpesviruses
title_sort mxb is an interferon-induced restriction factor of human herpesviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958057/
https://www.ncbi.nlm.nih.gov/pubmed/29773792
http://dx.doi.org/10.1038/s41467-018-04379-2
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