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The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway

PURPOSE: Protecting the heart from ischaemia-reperfusion (IR) injury is a major goal in patients presenting with an acute myocardial infarction. Pyroptosis is a novel form of cell death in which caspase 1 is activated and cleaves interleukin 1β. VX-785 is a highly selective, prodrug caspase 1 inhibi...

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Detalles Bibliográficos
Autores principales:	Do Carmo, Helison, Arjun, Sapna, Petrucci, Orlando, Yellon, Derek M, Davidson, Sean M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958154/ https://www.ncbi.nlm.nih.gov/pubmed/29582211 http://dx.doi.org/10.1007/s10557-018-6781-2

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