A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient

We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in r...

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Detalles Bibliográficos
Autores principales: Mohd Tap, Ratna, Lim, Teck Choon, Kamarudin, Nur Amalina, Ginsapu, Stephanie Jane, Abd Razak, Mohd Fuat, Ahmad, Norazah, Amran, Fairuz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958168/
https://www.ncbi.nlm.nih.gov/pubmed/29383574
http://dx.doi.org/10.1007/s11046-018-0244-y
Descripción
Sumario:We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested. The use of chromogenic agar as isolation media is vital in detecting mixed candidemia.

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