A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient

We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in r...

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Autores principales: Mohd Tap, Ratna, Lim, Teck Choon, Kamarudin, Nur Amalina, Ginsapu, Stephanie Jane, Abd Razak, Mohd Fuat, Ahmad, Norazah, Amran, Fairuz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958168/
https://www.ncbi.nlm.nih.gov/pubmed/29383574
http://dx.doi.org/10.1007/s11046-018-0244-y
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author Mohd Tap, Ratna
Lim, Teck Choon
Kamarudin, Nur Amalina
Ginsapu, Stephanie Jane
Abd Razak, Mohd Fuat
Ahmad, Norazah
Amran, Fairuz
author_facet Mohd Tap, Ratna
Lim, Teck Choon
Kamarudin, Nur Amalina
Ginsapu, Stephanie Jane
Abd Razak, Mohd Fuat
Ahmad, Norazah
Amran, Fairuz
author_sort Mohd Tap, Ratna
collection PubMed
description We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested. The use of chromogenic agar as isolation media is vital in detecting mixed candidemia.
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spelling pubmed-59581682018-05-18 A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient Mohd Tap, Ratna Lim, Teck Choon Kamarudin, Nur Amalina Ginsapu, Stephanie Jane Abd Razak, Mohd Fuat Ahmad, Norazah Amran, Fairuz Mycopathologia Short Communication We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested. The use of chromogenic agar as isolation media is vital in detecting mixed candidemia. Springer Netherlands 2018-01-30 2018 /pmc/articles/PMC5958168/ /pubmed/29383574 http://dx.doi.org/10.1007/s11046-018-0244-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Communication
Mohd Tap, Ratna
Lim, Teck Choon
Kamarudin, Nur Amalina
Ginsapu, Stephanie Jane
Abd Razak, Mohd Fuat
Ahmad, Norazah
Amran, Fairuz
A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient
title A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient
title_full A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient
title_fullStr A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient
title_full_unstemmed A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient
title_short A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient
title_sort fatal case of candida auris and candida tropicalis candidemia in neutropenic patient
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958168/
https://www.ncbi.nlm.nih.gov/pubmed/29383574
http://dx.doi.org/10.1007/s11046-018-0244-y
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