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Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects

We tested the hypothesis that dynamic hyperinflation develops in severe asthmatic subjects during exercise. Changes in inspiratory capacity (IC) were measured during the 6-min walk test (6MWT) in severe asthmatic subjects compared with chronic obstructive pulmonary disease (COPD) subjects with a sim...

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Autores principales: Benfante, Alida, Di Marco, Fabiano, Terraneo, Silvia, Centanni, Stefano, Scichilone, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958274/
https://www.ncbi.nlm.nih.gov/pubmed/29796391
http://dx.doi.org/10.1183/23120541.00143-2017
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author Benfante, Alida
Di Marco, Fabiano
Terraneo, Silvia
Centanni, Stefano
Scichilone, Nicola
author_facet Benfante, Alida
Di Marco, Fabiano
Terraneo, Silvia
Centanni, Stefano
Scichilone, Nicola
author_sort Benfante, Alida
collection PubMed
description We tested the hypothesis that dynamic hyperinflation develops in severe asthmatic subjects during exercise. Changes in inspiratory capacity (IC) were measured during the 6-min walk test (6MWT) in severe asthmatic subjects compared with chronic obstructive pulmonary disease (COPD) subjects with a similar degree of bronchial obstruction. We assessed whether changes in IC were associated with changes in dyspnoea perception. 27 severe asthmatic subjects (10 males and 17 females) and 43 COPD subjects (35 males and eight females) were recruited. The two groups performed similarly in the 6MWT (p=0.90). At the end of the test, the Borg score increased significantly in both groups (mean difference: for asthmatic subjects 1.7±1.6; p<0.0001; for COPD subjects 3.1±1.9; p<0.0001). IC measured at the beginning of 6MWT was not different between groups (2.25±0.47 L in asthmatic subjects versus 2.38±0.60 L in COPD subjects; p=0.32) and decreased in both groups (mean difference: for asthmatic subjects 0.160 L; p=0.02; for COPD subjects 0.164 L; p<0.0001). However, changes in IC were significantly associated with changes in the Borg score in the COPD group (r(2)=0.17; p=0.006), but not in the asthma group (r(2)=0.06; p=0.20). In severe asthmatic subjects, IC significantly drops during the 6MWT to the same extent as COPD subjects with a similar degree of lung impairment, indicating the development of dynamic hyperinflation. Contrary to COPD, in asthmatic subjects the occurrence of dynamic hyperinflation was not associated with changes in dyspnoea perception.
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spelling pubmed-59582742018-05-24 Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects Benfante, Alida Di Marco, Fabiano Terraneo, Silvia Centanni, Stefano Scichilone, Nicola ERJ Open Res Original Articles We tested the hypothesis that dynamic hyperinflation develops in severe asthmatic subjects during exercise. Changes in inspiratory capacity (IC) were measured during the 6-min walk test (6MWT) in severe asthmatic subjects compared with chronic obstructive pulmonary disease (COPD) subjects with a similar degree of bronchial obstruction. We assessed whether changes in IC were associated with changes in dyspnoea perception. 27 severe asthmatic subjects (10 males and 17 females) and 43 COPD subjects (35 males and eight females) were recruited. The two groups performed similarly in the 6MWT (p=0.90). At the end of the test, the Borg score increased significantly in both groups (mean difference: for asthmatic subjects 1.7±1.6; p<0.0001; for COPD subjects 3.1±1.9; p<0.0001). IC measured at the beginning of 6MWT was not different between groups (2.25±0.47 L in asthmatic subjects versus 2.38±0.60 L in COPD subjects; p=0.32) and decreased in both groups (mean difference: for asthmatic subjects 0.160 L; p=0.02; for COPD subjects 0.164 L; p<0.0001). However, changes in IC were significantly associated with changes in the Borg score in the COPD group (r(2)=0.17; p=0.006), but not in the asthma group (r(2)=0.06; p=0.20). In severe asthmatic subjects, IC significantly drops during the 6MWT to the same extent as COPD subjects with a similar degree of lung impairment, indicating the development of dynamic hyperinflation. Contrary to COPD, in asthmatic subjects the occurrence of dynamic hyperinflation was not associated with changes in dyspnoea perception. European Respiratory Society 2018-05-18 /pmc/articles/PMC5958274/ /pubmed/29796391 http://dx.doi.org/10.1183/23120541.00143-2017 Text en Copyright ©ERS 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Articles
Benfante, Alida
Di Marco, Fabiano
Terraneo, Silvia
Centanni, Stefano
Scichilone, Nicola
Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects
title Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects
title_full Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects
title_fullStr Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects
title_full_unstemmed Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects
title_short Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects
title_sort dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958274/
https://www.ncbi.nlm.nih.gov/pubmed/29796391
http://dx.doi.org/10.1183/23120541.00143-2017
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