Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB(2) Receptor Expression and Ligand Engagement in Human Cells

[Image: see text] Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB(2)R), a promising...

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Detalles Bibliográficos
Autores principales: Soethoudt, Marjolein, Stolze, Sara C., Westphal, Matthias V., van Stralen, Luuk, Martella, Andrea, van Rooden, Eva J., Guba, Wolfgang, Varga, Zoltan V., Deng, Hui, van Kasteren, Sander I., Grether, Uwe, IJzerman, Adriaan P., Pacher, Pal, Carreira, Erick M., Overkleeft, Herman S., Ioan-Facsinay, Andreea, Heitman, Laura H., van der Stelt, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958339/
https://www.ncbi.nlm.nih.gov/pubmed/29420021
http://dx.doi.org/10.1021/jacs.7b11281

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