Beating the odds: programming proliferation in the mammalian heart

The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle control. Recent insights into how myocytes can be coaxed into d...

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Detalles Bibliográficos
Autores principales: Jain, Rajan, Poleshko, Andrey, Epstein, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958408/
https://www.ncbi.nlm.nih.gov/pubmed/29776422
http://dx.doi.org/10.1186/s13073-018-0550-5
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author Jain, Rajan
Poleshko, Andrey
Epstein, Jonathan A.
author_facet Jain, Rajan
Poleshko, Andrey
Epstein, Jonathan A.
author_sort Jain, Rajan
collection PubMed
description The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle control. Recent insights into how myocytes can be coaxed into duplicating in vivo might inform emerging therapeutics.
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spelling pubmed-59584082018-05-24 Beating the odds: programming proliferation in the mammalian heart Jain, Rajan Poleshko, Andrey Epstein, Jonathan A. Genome Med Comment The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle control. Recent insights into how myocytes can be coaxed into duplicating in vivo might inform emerging therapeutics. BioMed Central 2018-05-18 /pmc/articles/PMC5958408/ /pubmed/29776422 http://dx.doi.org/10.1186/s13073-018-0550-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Jain, Rajan
Poleshko, Andrey
Epstein, Jonathan A.
Beating the odds: programming proliferation in the mammalian heart
title Beating the odds: programming proliferation in the mammalian heart
title_full Beating the odds: programming proliferation in the mammalian heart
title_fullStr Beating the odds: programming proliferation in the mammalian heart
title_full_unstemmed Beating the odds: programming proliferation in the mammalian heart
title_short Beating the odds: programming proliferation in the mammalian heart
title_sort beating the odds: programming proliferation in the mammalian heart
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958408/
https://www.ncbi.nlm.nih.gov/pubmed/29776422
http://dx.doi.org/10.1186/s13073-018-0550-5
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AT poleshkoandrey beatingtheoddsprogrammingproliferationinthemammalianheart
AT epsteinjonathana beatingtheoddsprogrammingproliferationinthemammalianheart

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