DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks

Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability. DNA damage checkpoint factors (DDCF) and DNA damage repair fa...

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Detalles Bibliográficos
Autores principales: Zeng, Huihong, Nanayakkara, Gayani K., Shao, Ying, Fu, Hangfei, Sun, Yu, Cueto, Ramon, Yang, William Y., Yang, Qian, Sheng, Haitao, Wu, Na, Wang, Luqiao, Yang, Wuping, Chen, Hongping, Shao, Lijian, Sun, Jianxin, Qin, Xuebin, Park, Joon Y., Drosatos, Konstantinos, Choi, Eric T., Zhu, Qingxian, Wang, Hong, Yang, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958474/
https://www.ncbi.nlm.nih.gov/pubmed/29867559
http://dx.doi.org/10.3389/fphys.2018.00516

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