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Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience

Anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) are very aggressive cancers whose histological diagnosis is not always straightforward. Clinical, pathological and genetic features may be useful to improve the identification of these rare histotypes. In the present study the clinical...

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Autores principales: Romei, Cristina, Tacito, Alessia, Molinaro, Eleonora, Piaggi, Paolo, Cappagli, Virginia, Pieruzzi, Letizia, Matrone, Antonio, Viola, David, Agate, Laura, Torregrossa, Liborio, Ugolini, Clara, Basolo, Fulvio, De Napoli, Luigi, Curcio, Michele, Ciampi, Raffaele, Materazzi, Gabriele, Vitti, Paolo, Elisei, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958691/
https://www.ncbi.nlm.nih.gov/pubmed/29805648
http://dx.doi.org/10.3892/ol.2018.8470
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author Romei, Cristina
Tacito, Alessia
Molinaro, Eleonora
Piaggi, Paolo
Cappagli, Virginia
Pieruzzi, Letizia
Matrone, Antonio
Viola, David
Agate, Laura
Torregrossa, Liborio
Ugolini, Clara
Basolo, Fulvio
De Napoli, Luigi
Curcio, Michele
Ciampi, Raffaele
Materazzi, Gabriele
Vitti, Paolo
Elisei, Rossella
author_facet Romei, Cristina
Tacito, Alessia
Molinaro, Eleonora
Piaggi, Paolo
Cappagli, Virginia
Pieruzzi, Letizia
Matrone, Antonio
Viola, David
Agate, Laura
Torregrossa, Liborio
Ugolini, Clara
Basolo, Fulvio
De Napoli, Luigi
Curcio, Michele
Ciampi, Raffaele
Materazzi, Gabriele
Vitti, Paolo
Elisei, Rossella
author_sort Romei, Cristina
collection PubMed
description Anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) are very aggressive cancers whose histological diagnosis is not always straightforward. Clinical, pathological and genetic features may be useful to improve the identification of these rare histotypes. In the present study the clinical, pathological and genetic features of two groups of ATC (n=21) and PDTC (n=21) patients were analyzed. Clinical data were retrieved from a computerized database. The oncogenic profiles were studied using the Sanger sequencing method of a selected series of oncogenes and/or tumor suppressor genes known to be altered in these tumors. The presence of macrophages in both series of tissues was evaluated by immunohistochemistry. Patients with ATC were older and affected by a more advanced disease at diagnosis than those with PDTC. The median survival was significantly shorter in ATC compared with PDTC patients (P=0.0014). ATC showed a higher prevalence of TP53 and TERT mutations (10/21, 47.6% and 9/21, 42.8%, respectively) while TERT and BRAF mutations were the most prevalent in the PDTC group (7/21, 33.3% and 4/23, 19% respectively). Genetic heterogeneity (i.e., >2 mutations) was more frequent in ATC (10/21, 28.6%) compared with in PDTC (3/21, 4.7%) (P=0.03). Macrophages were more frequently present in ATC, particularly in those cases with TP53 mutations. In conclusion, these data indicate that ATC and PDTC may be characterized by different clinical, pathological and genetic profiles. In particular ATC, but not PDTC, were positive for TP53 and PTEN alterations. Complex mutations were also found in ATC but not in PDTC. Moreover, genetic heterogeneity was more frequent in ATC than PDTC. Finally, TP53 mutation and the accumulation of several mutations correlated with a shorter survival time.
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spelling pubmed-59586912018-05-27 Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience Romei, Cristina Tacito, Alessia Molinaro, Eleonora Piaggi, Paolo Cappagli, Virginia Pieruzzi, Letizia Matrone, Antonio Viola, David Agate, Laura Torregrossa, Liborio Ugolini, Clara Basolo, Fulvio De Napoli, Luigi Curcio, Michele Ciampi, Raffaele Materazzi, Gabriele Vitti, Paolo Elisei, Rossella Oncol Lett Articles Anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) are very aggressive cancers whose histological diagnosis is not always straightforward. Clinical, pathological and genetic features may be useful to improve the identification of these rare histotypes. In the present study the clinical, pathological and genetic features of two groups of ATC (n=21) and PDTC (n=21) patients were analyzed. Clinical data were retrieved from a computerized database. The oncogenic profiles were studied using the Sanger sequencing method of a selected series of oncogenes and/or tumor suppressor genes known to be altered in these tumors. The presence of macrophages in both series of tissues was evaluated by immunohistochemistry. Patients with ATC were older and affected by a more advanced disease at diagnosis than those with PDTC. The median survival was significantly shorter in ATC compared with PDTC patients (P=0.0014). ATC showed a higher prevalence of TP53 and TERT mutations (10/21, 47.6% and 9/21, 42.8%, respectively) while TERT and BRAF mutations were the most prevalent in the PDTC group (7/21, 33.3% and 4/23, 19% respectively). Genetic heterogeneity (i.e., >2 mutations) was more frequent in ATC (10/21, 28.6%) compared with in PDTC (3/21, 4.7%) (P=0.03). Macrophages were more frequently present in ATC, particularly in those cases with TP53 mutations. In conclusion, these data indicate that ATC and PDTC may be characterized by different clinical, pathological and genetic profiles. In particular ATC, but not PDTC, were positive for TP53 and PTEN alterations. Complex mutations were also found in ATC but not in PDTC. Moreover, genetic heterogeneity was more frequent in ATC than PDTC. Finally, TP53 mutation and the accumulation of several mutations correlated with a shorter survival time. D.A. Spandidos 2018-06 2018-04-12 /pmc/articles/PMC5958691/ /pubmed/29805648 http://dx.doi.org/10.3892/ol.2018.8470 Text en Copyright: © Romei et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Romei, Cristina
Tacito, Alessia
Molinaro, Eleonora
Piaggi, Paolo
Cappagli, Virginia
Pieruzzi, Letizia
Matrone, Antonio
Viola, David
Agate, Laura
Torregrossa, Liborio
Ugolini, Clara
Basolo, Fulvio
De Napoli, Luigi
Curcio, Michele
Ciampi, Raffaele
Materazzi, Gabriele
Vitti, Paolo
Elisei, Rossella
Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience
title Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience
title_full Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience
title_fullStr Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience
title_full_unstemmed Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience
title_short Clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: A single institute experience
title_sort clinical, pathological and genetic features of anaplastic and poorly differentiated thyroid cancer: a single institute experience
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958691/
https://www.ncbi.nlm.nih.gov/pubmed/29805648
http://dx.doi.org/10.3892/ol.2018.8470
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