Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report

We report a rare case of primary amelanotic malignant melanoma of the male urethra. A 65-year-old man with a urethral mass was referred to our hospital. A pathological diagnosis of a biopsy specimen revealed malignant melanoma. Thereafter, the patient underwent partial penectomy. The histopathologic...

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Autores principales: Tokita, Takashi, Kawahara, Takashi, Ito, Yusuke, Tsutsumi, Sohgo, Abe, Koichi, Namura, Kazuhiro, Sano, Futoshi, Shioi, Koichi, Takamoto, Daiji, Yumura, Yasushi, Nakaigawa, Noboru, Yao, Masahiro, Uemura, Hiroji, Wada, Hidefumi, Tsuura, Yukio, Kobayashi, Kazuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958931/
https://www.ncbi.nlm.nih.gov/pubmed/29785370
http://dx.doi.org/10.1016/j.eucr.2018.03.006
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author Tokita, Takashi
Kawahara, Takashi
Ito, Yusuke
Tsutsumi, Sohgo
Abe, Koichi
Namura, Kazuhiro
Sano, Futoshi
Shioi, Koichi
Takamoto, Daiji
Yumura, Yasushi
Nakaigawa, Noboru
Yao, Masahiro
Uemura, Hiroji
Wada, Hidefumi
Tsuura, Yukio
Kobayashi, Kazuki
author_facet Tokita, Takashi
Kawahara, Takashi
Ito, Yusuke
Tsutsumi, Sohgo
Abe, Koichi
Namura, Kazuhiro
Sano, Futoshi
Shioi, Koichi
Takamoto, Daiji
Yumura, Yasushi
Nakaigawa, Noboru
Yao, Masahiro
Uemura, Hiroji
Wada, Hidefumi
Tsuura, Yukio
Kobayashi, Kazuki
author_sort Tokita, Takashi
collection PubMed
description We report a rare case of primary amelanotic malignant melanoma of the male urethra. A 65-year-old man with a urethral mass was referred to our hospital. A pathological diagnosis of a biopsy specimen revealed malignant melanoma. Thereafter, the patient underwent partial penectomy. The histopathological diagnosis was amelanotic malignant melanoma of the urethra. The patient had received DAV-Feron in an adjuvant setting; however, PET-CT revealed multiple metastasis. After receiving more than 10 cycles of nivolumab, the accumulation of FDG was no longer observed on PET-CT. The patient is currently free from recurrence at 20 months after nivolumab treatment.
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spelling pubmed-59589312018-05-21 Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report Tokita, Takashi Kawahara, Takashi Ito, Yusuke Tsutsumi, Sohgo Abe, Koichi Namura, Kazuhiro Sano, Futoshi Shioi, Koichi Takamoto, Daiji Yumura, Yasushi Nakaigawa, Noboru Yao, Masahiro Uemura, Hiroji Wada, Hidefumi Tsuura, Yukio Kobayashi, Kazuki Urol Case Rep Oncology We report a rare case of primary amelanotic malignant melanoma of the male urethra. A 65-year-old man with a urethral mass was referred to our hospital. A pathological diagnosis of a biopsy specimen revealed malignant melanoma. Thereafter, the patient underwent partial penectomy. The histopathological diagnosis was amelanotic malignant melanoma of the urethra. The patient had received DAV-Feron in an adjuvant setting; however, PET-CT revealed multiple metastasis. After receiving more than 10 cycles of nivolumab, the accumulation of FDG was no longer observed on PET-CT. The patient is currently free from recurrence at 20 months after nivolumab treatment. Elsevier 2018-03-13 /pmc/articles/PMC5958931/ /pubmed/29785370 http://dx.doi.org/10.1016/j.eucr.2018.03.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Tokita, Takashi
Kawahara, Takashi
Ito, Yusuke
Tsutsumi, Sohgo
Abe, Koichi
Namura, Kazuhiro
Sano, Futoshi
Shioi, Koichi
Takamoto, Daiji
Yumura, Yasushi
Nakaigawa, Noboru
Yao, Masahiro
Uemura, Hiroji
Wada, Hidefumi
Tsuura, Yukio
Kobayashi, Kazuki
Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report
title Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report
title_full Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report
title_fullStr Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report
title_full_unstemmed Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report
title_short Primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: A case report
title_sort primary amelanotic malignant melanoma of the male urethra with inguinal lymph node metastasis successfully controlled by nivolumab: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958931/
https://www.ncbi.nlm.nih.gov/pubmed/29785370
http://dx.doi.org/10.1016/j.eucr.2018.03.006
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