LncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca(2+) Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction

RATIONALE: Ca(2+) homeostasis—a critical determinant of cardiac contractile function—is critically regulated by SERCA2a (sarcoplasmic reticulum Ca(2+)-ATPase 2a). Our previous study has identified ZFAS1 as a new lncRNA biomarker of acute myocardial infarction (MI). OBJECTIVE: To evaluate the effects...

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Detalles Bibliográficos
Autores principales: Zhang, Ying, Jiao, Lei, Sun, Lihua, Li, Yanru, Gao, Yuqiu, Xu, Chaoqian, Shao, Yingchun, Li, Mengmeng, Li, Chunyan, Lu, Yanjie, Pan, Zhenwei, Xuan, Lina, Zhang, Yiyuan, Li, Qingqi, Yang, Rui, Zhuang, Yuting, Zhang, Yong, Yang, Baofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Cellular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959220/
https://www.ncbi.nlm.nih.gov/pubmed/29475982
http://dx.doi.org/10.1161/CIRCRESAHA.117.312117

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