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A complex mTOR response in habituation paradigms for a social signal in adult songbirds
Nonassociative learning is considered simple because it depends on presentation of a single stimulus, but it likely reflects complex molecular signaling. To advance understanding of the molecular mechanisms of one form of nonassociative learning, habituation, for ethologically relevant signals we ex...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959225/ https://www.ncbi.nlm.nih.gov/pubmed/29764973 http://dx.doi.org/10.1101/lm.046417.117 |
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author | Ahmadiantehrani, Somayeh Gores, Elisa O. London, Sarah E. |
author_facet | Ahmadiantehrani, Somayeh Gores, Elisa O. London, Sarah E. |
author_sort | Ahmadiantehrani, Somayeh |
collection | PubMed |
description | Nonassociative learning is considered simple because it depends on presentation of a single stimulus, but it likely reflects complex molecular signaling. To advance understanding of the molecular mechanisms of one form of nonassociative learning, habituation, for ethologically relevant signals we examined song recognition learning in adult zebra finches. These colonial songbirds learn the unique song of individuals, which helps establish and maintain mate and other social bonds, and informs appropriate behavioral interactions with specific birds. We leveraged prior work demonstrating behavioral habituation for individual songs, and extended the molecular framework correlated with this behavior by investigating the mechanistic Target of Rapamycin (mTOR) signaling cascade. We hypothesized that mTOR may contribute to habituation because it integrates a variety of upstream signals and enhances associative learning, and it crosstalks with another cascade previously associated with habituation, ERK/ZENK. To begin probing for a possible role for mTOR in song recognition learning, we used a combination of song playback paradigms and bidirectional dysregulation of mTORC1 activation. We found that mTOR demonstrates the molecular signatures of a habituation mechanism, and that its manipulation reveals the complexity of processes that may be invoked during nonassociative learning. These results thus expand the molecular targets for habituation studies and raise new questions about neural processing of complex natural signals. |
format | Online Article Text |
id | pubmed-5959225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59592252019-06-01 A complex mTOR response in habituation paradigms for a social signal in adult songbirds Ahmadiantehrani, Somayeh Gores, Elisa O. London, Sarah E. Learn Mem Research Nonassociative learning is considered simple because it depends on presentation of a single stimulus, but it likely reflects complex molecular signaling. To advance understanding of the molecular mechanisms of one form of nonassociative learning, habituation, for ethologically relevant signals we examined song recognition learning in adult zebra finches. These colonial songbirds learn the unique song of individuals, which helps establish and maintain mate and other social bonds, and informs appropriate behavioral interactions with specific birds. We leveraged prior work demonstrating behavioral habituation for individual songs, and extended the molecular framework correlated with this behavior by investigating the mechanistic Target of Rapamycin (mTOR) signaling cascade. We hypothesized that mTOR may contribute to habituation because it integrates a variety of upstream signals and enhances associative learning, and it crosstalks with another cascade previously associated with habituation, ERK/ZENK. To begin probing for a possible role for mTOR in song recognition learning, we used a combination of song playback paradigms and bidirectional dysregulation of mTORC1 activation. We found that mTOR demonstrates the molecular signatures of a habituation mechanism, and that its manipulation reveals the complexity of processes that may be invoked during nonassociative learning. These results thus expand the molecular targets for habituation studies and raise new questions about neural processing of complex natural signals. Cold Spring Harbor Laboratory Press 2018-06 /pmc/articles/PMC5959225/ /pubmed/29764973 http://dx.doi.org/10.1101/lm.046417.117 Text en © 2018 Ahmadiantehrani et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Ahmadiantehrani, Somayeh Gores, Elisa O. London, Sarah E. A complex mTOR response in habituation paradigms for a social signal in adult songbirds |
title | A complex mTOR response in habituation paradigms for a social signal in adult songbirds |
title_full | A complex mTOR response in habituation paradigms for a social signal in adult songbirds |
title_fullStr | A complex mTOR response in habituation paradigms for a social signal in adult songbirds |
title_full_unstemmed | A complex mTOR response in habituation paradigms for a social signal in adult songbirds |
title_short | A complex mTOR response in habituation paradigms for a social signal in adult songbirds |
title_sort | complex mtor response in habituation paradigms for a social signal in adult songbirds |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959225/ https://www.ncbi.nlm.nih.gov/pubmed/29764973 http://dx.doi.org/10.1101/lm.046417.117 |
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