Athymic mice reveal a requirement for T-cell–microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth

Pediatric low-grade gliomas (LGGs) frequently do not engraft in immunocompromised mice, limiting their use as an experimental platform. In contrast, murine Neurofibromatosis-1 (Nf1) optic LGG stem cells (o-GSCs) form glioma-like lesions in wild-type, but not athymic, mice following transplantation....

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Detalles Bibliográficos
Autores principales: Pan, Yuan, Xiong, Min, Chen, Ran, Ma, Yu, Corman, Courtney, Maricos, Meron, Kindler, Urs, Semtner, Marcus, Chen, Yi-Hsien, Dahiya, Sonika, Gutmann, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959233/
https://www.ncbi.nlm.nih.gov/pubmed/29632086
http://dx.doi.org/10.1101/gad.310797.117

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