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ERF deletion rescues RAS deficiency in mouse embryonic stem cells

MEK inhibition in combination with a glycogen synthase kinase-3β (GSK3β) inhibitor, referred as the 2i condition, favors pluripotency in embryonic stem cells (ESCs). However, the mechanisms by which the 2i condition limits ESC differentiation and whether RAS proteins are involved in this phenomenon...

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Detalles Bibliográficos
Autores principales:	Mayor-Ruiz, Cristina, Olbrich, Teresa, Drosten, Matthias, Lecona, Emilio, Vega-Sendino, Maria, Ortega, Sagrario, Dominguez, Orlando, Barbacid, Mariano, Ruiz, Sergio, Fernandez-Capetillo, Oscar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959239/ https://www.ncbi.nlm.nih.gov/pubmed/29650524 http://dx.doi.org/10.1101/gad.310086.117

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