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Prp8 positioning of U5 snRNA is linked to 5′ splice site recognition

Prp8 is an essential protein that regulates spliceosome assembly and conformation during pre-mRNA splicing. Recent cryo-EM structures of the spliceosome model Prp8 as a scaffold for the spliceosome's catalytic U snRNA components. Using a new amino acid probing strategy, we identified a dynamic...

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Detalles Bibliográficos
Autores principales:	MacRae, Andrew J., Mayerle, Megan, Hrabeta-Robinson, Eva, Chalkley, Robert J., Guthrie, Christine, Burlingame, Alma L., Jurica, Melissa S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2018
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959246/ https://www.ncbi.nlm.nih.gov/pubmed/29487104 http://dx.doi.org/10.1261/rna.065458.117

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