Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis

Recognition of dsRNA molecules activates the MDA5–MAVS pathway and plays a critical role in stimulating type-I interferon responses in psoriasis. However, the source of the dsRNA accumulation in psoriatic keratinocytes remains largely unknown. A-to-I RNA editing is a common co- or post-transcription...

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Detalles Bibliográficos
Autores principales: Shallev, Lea, Kopel, Eli, Feiglin, Ariel, Leichner, Gil S., Avni, Dror, Sidi, Yechezkel, Eisenberg, Eli, Barzilai, Aviv, Levanon, Erez Y., Greenberger, Shoshana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959251/
https://www.ncbi.nlm.nih.gov/pubmed/29592874
http://dx.doi.org/10.1261/rna.064659.117

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