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Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection
Innovation in medicine is a dynamic, complex, and continuous process that cannot be isolated to a single moment in time. Anniversaries offer opportunities to commemorate crucial discoveries of modern medicine, such as penicillin (1928), polio vaccination (inactivated, 1955; oral, 1961), the surface...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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JAIDS Journal of Acquired Immune Deficiency Syndromes
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959256/ https://www.ncbi.nlm.nih.gov/pubmed/29474268 http://dx.doi.org/10.1097/QAI.0000000000001660 |
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author | Quercia, Romina Perno, Carlo-Federico Koteff, Justin Moore, Katy McCoig, Cynthia St. Clair, Marty Kuritzkes, Daniel |
author_facet | Quercia, Romina Perno, Carlo-Federico Koteff, Justin Moore, Katy McCoig, Cynthia St. Clair, Marty Kuritzkes, Daniel |
author_sort | Quercia, Romina |
collection | PubMed |
description | Innovation in medicine is a dynamic, complex, and continuous process that cannot be isolated to a single moment in time. Anniversaries offer opportunities to commemorate crucial discoveries of modern medicine, such as penicillin (1928), polio vaccination (inactivated, 1955; oral, 1961), the surface antigen of the hepatitis B virus (1967), monoclonal antibodies (1975), and the first HIV antiretroviral drugs (zidovudine, 1987). The advent of antiretroviral drugs has had a profound effect on the progress of the epidemiology of HIV infection, transforming a terminal, irreversible disease that caused a global health crisis into a treatable but chronic disease. This result has been driven by the success of antiretroviral drug combinations that include nucleoside reverse transcriptase inhibitors such as lamivudine. Lamivudine, an L-enantiomeric analog of cytosine, potently affects HIV replication by inhibiting viral reverse transcriptase enzymes at concentrations without toxicity against human polymerases. Although lamivudine was approved more than 2 decades ago, it remains a key component of first-line therapy for HIV because of its virological efficacy and ability to be partnered with other antiretroviral agents in traditional and novel combination therapies. The prominence of lamivudine in HIV therapy is highlighted by its incorporation in recent innovative treatment strategies, such as single-tablet regimens that address challenges associated with regimen complexity and treatment adherence and 2-drug regimens being developed to mitigate cumulative drug exposure and toxicities. This review summarizes how the pharmacologic and virologic properties of lamivudine have solidified its role in contemporary HIV therapy and continue to support its use in emerging therapies. |
format | Online Article Text |
id | pubmed-5959256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | JAIDS Journal of Acquired Immune Deficiency Syndromes |
record_format | MEDLINE/PubMed |
spelling | pubmed-59592562018-06-01 Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection Quercia, Romina Perno, Carlo-Federico Koteff, Justin Moore, Katy McCoig, Cynthia St. Clair, Marty Kuritzkes, Daniel J Acquir Immune Defic Syndr Critical Review Innovation in medicine is a dynamic, complex, and continuous process that cannot be isolated to a single moment in time. Anniversaries offer opportunities to commemorate crucial discoveries of modern medicine, such as penicillin (1928), polio vaccination (inactivated, 1955; oral, 1961), the surface antigen of the hepatitis B virus (1967), monoclonal antibodies (1975), and the first HIV antiretroviral drugs (zidovudine, 1987). The advent of antiretroviral drugs has had a profound effect on the progress of the epidemiology of HIV infection, transforming a terminal, irreversible disease that caused a global health crisis into a treatable but chronic disease. This result has been driven by the success of antiretroviral drug combinations that include nucleoside reverse transcriptase inhibitors such as lamivudine. Lamivudine, an L-enantiomeric analog of cytosine, potently affects HIV replication by inhibiting viral reverse transcriptase enzymes at concentrations without toxicity against human polymerases. Although lamivudine was approved more than 2 decades ago, it remains a key component of first-line therapy for HIV because of its virological efficacy and ability to be partnered with other antiretroviral agents in traditional and novel combination therapies. The prominence of lamivudine in HIV therapy is highlighted by its incorporation in recent innovative treatment strategies, such as single-tablet regimens that address challenges associated with regimen complexity and treatment adherence and 2-drug regimens being developed to mitigate cumulative drug exposure and toxicities. This review summarizes how the pharmacologic and virologic properties of lamivudine have solidified its role in contemporary HIV therapy and continue to support its use in emerging therapies. JAIDS Journal of Acquired Immune Deficiency Syndromes 2018-06-01 2018-02-22 /pmc/articles/PMC5959256/ /pubmed/29474268 http://dx.doi.org/10.1097/QAI.0000000000001660 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Critical Review Quercia, Romina Perno, Carlo-Federico Koteff, Justin Moore, Katy McCoig, Cynthia St. Clair, Marty Kuritzkes, Daniel Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection |
title | Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection |
title_full | Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection |
title_fullStr | Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection |
title_full_unstemmed | Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection |
title_short | Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection |
title_sort | twenty-five years of lamivudine: current and future use for the treatment of hiv-1 infection |
topic | Critical Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959256/ https://www.ncbi.nlm.nih.gov/pubmed/29474268 http://dx.doi.org/10.1097/QAI.0000000000001660 |
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